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Mendeley readers
| Title |
The Fate of Reconstructive Surgery Following Colectomy for Inflammatory Bowel Disease in Sweden: A Population-based Cohort Study
|
|---|---|
| Published in |
Journal of Crohn's and Colitis Supplements, March 2016
|
| DOI | 10.1093/ecco-jcc/jjw073 |
| Pubmed ID | |
| Authors |
Caroline Nordenvall, Ola Olén, Per J. Nilsson, Anders Ekbom, Matteo Bottai, Pär Myrelid |
| Abstract |
Previous studies describing the cumulative failure rate after reconstructive surgery in patients with inflammatory bowel disease have been restricted to specific hospitals, and the generalizability of these results in a population-based setting is unknown. The aim with this study was to investigate the cumulative failure rate and risk factors for failure after reconstructive surgery in patients with inflammatory bowel disease. The study cohort includes all patients with inflammatory bowel disease in Sweden who underwent colectomy in 2000 through 2013 that were later treated with reconstructive surgery with ileal anal pouch anastomosis or ileorectal anastomosis. Each patient was followed from admission for reconstructive surgery until admission for failure (a diverting stoma or permanent stoma), date of death, migration or December 31(st) 2013. Cumulative failure distributions were obtained with Kaplan-Meier method and multivariable Cox regression models were used to calculate the risk of failure. Of the 1809 patients with inflammatory bowel disease treated with colectomy and reconstructive surgery, 83% had ulcerative colitis. During follow-up 270 patients failed, and the cumulative failure rate was 4.1%, 13.2%, and 15.3% after 1, 3, and 5 years respectively. The risk of failure was lower after treatment with ileal anal pouch anastomosis than ileorectal anastomosis (Hazard Ratio and 95% confidence interval: 0.72 (0.56-0.93)). Gender, hospital volume and timing of reconstruction were not significantly associated with the risk of failure. The 5-year cumulative failure rate in a nationwide setting was 15.3%, and hospital volume was not associated with the risk of failure. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 7 | 21% |
| Student > Bachelor | 6 | 18% |
| Student > Master | 5 | 15% |
| Student > Ph. D. Student | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 8 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 50% |
| Psychology | 2 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Environmental Science | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 32% |