Title |
Opioid-Induced Hyperalgesia: Clinically Relevant or Extraneous Research Phenomenon?
|
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Published in |
Current Pain and Headache Reports, January 2011
|
DOI | 10.1007/s11916-010-0171-1 |
Pubmed ID | |
Authors |
D. Andrew Tompkins, Claudia M. Campbell |
Abstract |
Opioids have become the unequivocal therapy of choice in treating many varieties of chronic pain. With the increased prescription of opioids, some unintended consequences have occurred. After prolonged opioid exposure, opioid-induced hyperalgesia (OIH), the paradoxical effect that opioid therapy may in fact enhance or aggravate preexisting pain, may occur. Over the past several decades, an increasing number of laboratory and clinical reports have suggested lowered pain thresholds and heightened atypical pain unrelated to the original perceived pain sensations as hallmarks of OIH. However, not all evidence supports the clinical importance of OIH, and some question whether the phenomenon exists at all. Here, we present a nonexhaustive, brief review of the recent literature. OIH will be reviewed in terms of preclinical and clinical evidence for and against its existence; recommendations for clinical evaluation and intervention also will be discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 6 | 40% |
United Kingdom | 1 | 7% |
Unknown | 8 | 53% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 14 | 93% |
Unknown | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Netherlands | 1 | <1% |
Unknown | 111 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 18 | 16% |
Researcher | 13 | 11% |
Student > Doctoral Student | 12 | 11% |
Student > Postgraduate | 10 | 9% |
Student > Bachelor | 9 | 8% |
Other | 31 | 27% |
Unknown | 21 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 51 | 45% |
Agricultural and Biological Sciences | 7 | 6% |
Psychology | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 15 | 13% |
Unknown | 26 | 23% |