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Mendeley readers
Attention Score in Context
| Title |
Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels
|
|---|---|
| Published in |
Journal of Neurophysiology, December 2011
|
| DOI | 10.1152/jn.01066.2011 |
| Pubmed ID | |
| Authors |
Andrew J. Delaney, John M. Power, Pankaj Sah |
| Abstract |
Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC(50) of ~10 μM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 9% |
| United Kingdom | 1 | 3% |
| Spain | 1 | 3% |
| Italy | 1 | 3% |
| Unknown | 29 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 29% |
| Researcher | 10 | 29% |
| Professor | 5 | 14% |
| Professor > Associate Professor | 2 | 6% |
| Student > Bachelor | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 49% |
| Neuroscience | 7 | 20% |
| Medicine and Dentistry | 3 | 9% |
| Psychology | 1 | 3% |
| Materials Science | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 6 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2012.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Journal of Neurophysiology
#5,234
of 8,423 outputs
Outputs of similar age
#172,151
of 249,538 outputs
Outputs of similar age from Journal of Neurophysiology
#28
of 70 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,423 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,538 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.