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Mendeley readers
Attention Score in Context
| Title |
NK Cell Deficiency Predisposes to Viral-Induced Th2-Type Allergic Inflammation via Epithelial-Derived IL-25
|
|---|---|
| Published in |
The Journal of Immunology, October 2010
|
| DOI | 10.4049/jimmunol.1001758 |
| Pubmed ID | |
| Authors |
Gerard E. Kaiko, Simon Phipps, Pornpimon Angkasekwinai, Chen Dong, Paul S. Foster |
| Abstract |
Severe respiratory syncytial virus (RSV) infection has long been associated with an increased risk for the development of childhood asthma and exacerbations of this disorder. Despite much research into the induction of Th2 responses by allergens and helminths, the factors associated with viral infection that predispose to Th2-regulated asthma remain unknown. Recently, clinical studies have shown reduced numbers of NK cells in infants suffering from a severe RSV infection. Here we demonstrate that NK cell deficiency during primary RSV infection of BALB/c mice results in the suppression of IFN-γ production and the development of an RSV-specific Th2 response and subsequent allergic lung disease. The outgrowth of the Th2 responses was dependent on airway epithelial cell-derived IL-25, which induced the upregulation of the notch ligand Jagged1 on dendritic cells. This study identifies a novel pathway underlying viral-driven Th2 responses that may have functional relevance to viral-associated asthma. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Spain | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 98 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 27% |
| Researcher | 19 | 19% |
| Student > Bachelor | 11 | 11% |
| Student > Master | 10 | 10% |
| Professor | 4 | 4% |
| Other | 11 | 11% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 27% |
| Immunology and Microbiology | 24 | 24% |
| Medicine and Dentistry | 19 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Mathematics | 1 | <1% |
| Other | 5 | 5% |
| Unknown | 19 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2014.
All research outputs
#15,329,366
of 23,577,761 outputs
Outputs from The Journal of Immunology
#24,008
of 27,978 outputs
Outputs of similar age
#80,550
of 100,682 outputs
Outputs of similar age from The Journal of Immunology
#155
of 181 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 27,978 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 181 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.