| Title |
Adipose tissue macrophages: going off track during obesity
|
|---|---|
| Published in |
Diabetologia, March 2016
|
| DOI | 10.1007/s00125-016-3904-9 |
| Pubmed ID | |
| Authors |
Lily Boutens, Rinke Stienstra |
| Abstract |
Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean and obese conditions. Both conventional and tissue-specific functions of adipose tissue macrophages (ATMs) in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity. Furthermore, we will address various circulating and adipose tissue-derived triggers that may be involved in shaping the ATM phenotype and underlie ATM function in lean and obese conditions. Finally, we will highlight how these changes affect adipose tissue inflammation and may be targeted for therapeutic interventions to improve insulin sensitivity in obese individuals. Highlights • Macrophages play a significant role in regulating adipose tissue functioning during health and disease • In addition to conventional functions such as clearing cellular debris and participating in tissue immune surveillance, lipid buffering is an important function of ATMs • Obesity-induced inflammation, characterised by an elevated number of proinflammatory macrophages in adipose tissue, has been suggested to contribute to systemic insulin resistance • Their origin, as well as a combination of peripheral changes and adipose tissue-derived stressors, probably contribute to ATM dysfunction and inflammatory traits during obesity • Identification of transcriptional differences between ATMs from lean vs obese adipose tissue at several key points during the development of obesity and insulin resistance may reveal upstream triggers, regulatory factors and intracellular pathways that shape ATM function • Targeting metabolic capacity rather than the inflammatory phenotype of ATMs may hold potential to restore ATM function and adipose tissue homeostasis in obese individuals. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 6% |
| United States | 1 | 6% |
| Denmark | 1 | 6% |
| Australia | 1 | 6% |
| Brazil | 1 | 6% |
| Venezuela, Bolivarian Republic of | 1 | 6% |
| Unknown | 10 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 75% |
| Scientists | 3 | 19% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 481 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 1 | <1% |
| Chile | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 474 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 91 | 19% |
| Student > Master | 85 | 18% |
| Student > Bachelor | 69 | 14% |
| Researcher | 53 | 11% |
| Student > Doctoral Student | 22 | 5% |
| Other | 68 | 14% |
| Unknown | 93 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 119 | 25% |
| Agricultural and Biological Sciences | 78 | 16% |
| Medicine and Dentistry | 60 | 12% |
| Immunology and Microbiology | 37 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 3% |
| Other | 58 | 12% |
| Unknown | 114 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2022.
All research outputs
#2,366,000
of 25,301,208 outputs
Outputs from Diabetologia
#1,216
of 5,334 outputs
Outputs of similar age
#36,139
of 305,300 outputs
Outputs of similar age from Diabetologia
#21
of 81 outputs
Altmetric has tracked 25,301,208 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,334 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,300 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.