Title |
Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia
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Published in |
Prenatal Diagnosis, April 2016
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DOI | 10.1002/pd.4811 |
Pubmed ID | |
Authors |
Alejandra Chaparro, Dominique Gaedechens, Valeria Ramírez, Edgardo Zuñiga, Juan Pedro Kusanovic, Carolina Inostroza, Manuel Varas-Godoy, Karla Silva, Carlos Salomon, Gregory Rice, Sebastián Enrique Illanes |
Abstract |
to explore the feasibility of measuring endothelial and placental biomarkers in saliva and gingival crevicular fluid (GCF), and to determine if patients with PE have a different profile of these biomarkers in oral fluids. Method A case-control study was conducted, including patients with PE (n = 10) and a control group with normal pregnancies randomly selected (n = 20) admitted at the Sótero del Río Hospital in Santiago, Chile. A complete periodontal and obstetric history, involved the collection of oral fluids were performed at the same gestational age. Levels of Cd63+ extracellular-vesicles, placental alkaline phosphatase (PLAP), placental growth factor (PlGF) and sFlt-1 levels were determined by ELISA assays. Data analysis was performed with Chi-square or Fisher's exact test, and Mann-Whitney U test for continuous variables. The association was assessed using a multiple logistic regression model. sFlt-1 concentrations in saliva and GCF were significantly higher in patients with PE (p = 0.045 and p = 0.033 respectively). Concentrations of PLAP were elevated in GCF of PE patients (p = 0.049). The PLAP/CD63+ ratio in GCF of PE patients was significantly higher (p = 0.0008). No differences in PlGF levels were observed. GCF of PE patient's concentrates higher levels of biomarkers related with the PE development. This article is protected by copyright. All rights reserved. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 12% |
Researcher | 10 | 12% |
Student > Master | 8 | 10% |
Professor > Associate Professor | 6 | 7% |
Student > Doctoral Student | 4 | 5% |
Other | 16 | 20% |
Unknown | 27 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 29 | 36% |
Biochemistry, Genetics and Molecular Biology | 9 | 11% |
Agricultural and Biological Sciences | 3 | 4% |
Nursing and Health Professions | 2 | 2% |
Business, Management and Accounting | 2 | 2% |
Other | 7 | 9% |
Unknown | 29 | 36% |