| Title |
Monoclonal antibody markers for early development of the stereociliary bundles of mammalian hair cells
|
|---|---|
| Published in |
Brain Cell Biology, November 1995
|
| DOI | 10.1007/bf01179984 |
| Pubmed ID | |
| Authors |
M. C. Holley, Y. Nishida |
| Abstract |
Two monoclonal antibodies, SC1 and SC2, were raised in vitro against antigens from the stereocilia of guinea-pig hair cells. They both labelled stereociliary antigens that were not detected in any other cell within the cochlear duct or the vestibular epithelial. SC1 cross-reacted with the tectorial membrane in the cochlea and labelled both cochlear and vestibular hair cells from both the mouse and the rat. In the mouse the SC1 antigen was labelled from embryonic days 16-18, coincident with the development of the stereociliary bundles. SC1 cross-reacted with neuromuscular junctions from striated muscle and with basal keratinocytes in skin. SC2 did not cross-react cleanly with hair cells from the mouse or the rat but it cross-reacted with proximal tubules of the guinea-pig kidney. Both antibodies can be used as cellular markers within the guinea-pig cochlea and SC1 should be particularly useful for studies of hair cell differentiation in the mouse. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 33% |
| Professor > Associate Professor | 1 | 17% |
| Researcher | 1 | 17% |
| Unknown | 2 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 50% |
| Neuroscience | 1 | 17% |
| Unknown | 2 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2005.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Brain Cell Biology
#46
of 202 outputs
Outputs of similar age
#7,166
of 23,247 outputs
Outputs of similar age from Brain Cell Biology
#1
of 4 outputs
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