| Title |
Utility of fractional excretion of urea in the differential diagnosis of acute kidney injury in children
|
|---|---|
| Published in |
Pediatric Nephrology, March 2016
|
| DOI | 10.1007/s00467-016-3366-9 |
| Pubmed ID | |
| Authors |
Hisayo Fujita, Masayoshi Shinjoh, Tomohiro Ishii, Midori Awazu |
| Abstract |
The fractional excretion of sodium (FENa) has been used as an index for the differential diagnosis of acute tubular necrosis (ATN) and prerenal acute kidney injury (AKI). The reliability of this index, however, decreases with the use of the diuretic agent furosemide. The fractional excretion of urea nitrogen (FEUN) has been shown to be useful in such settings in adults. The objective of this study was to examine whether FEUN is also useful in these settings in children. We assessed 102 episodes of AKI in 74 children, classifying these into three groups based on history, physical examination, urine examination and subsequent clinical course: (1) prerenal AKI without furosemide (N = 37), (2) prerenal AKI with furosemide (N = 32) and (3) ATN (N = 33). Of the 37 prerenal AKI episodes without furosemide, 35 showed low FENa of <1 %, with an overall average of 0.35 ± 0.11 %, whereas prerenal AKI with furosemide (1.63 ± 0.37 %) and ATN (8.76 ± 2.11 %) were associated with a higher FENa. FEUN in the clinical setting of prerenal AKI was lower than that in ATN (27.9 ± 2.1 vs. 51.6 ± 3.8 %, respectively) and, in contrast to FENa, not significantly different between the categories of prerenal AKI with and without furosemide (29.2 ± 3.1 vs. 25.1 ± 2.9, respectively). The sensitivity of FEUN <35 % was 75 % in prerenal AKI with furosemide, whereas that of FENa was 53 %. FEUN is useful in detecting prerenal AKI in children administered furosemide. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 23% |
| Student > Doctoral Student | 3 | 14% |
| Researcher | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Student > Postgraduate | 2 | 9% |
| Other | 4 | 18% |
| Unknown | 4 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 50% |
| Nursing and Health Professions | 2 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Sports and Recreations | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 6 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2016.
All research outputs
#13,945,718
of 23,120,280 outputs
Outputs from Pediatric Nephrology
#2,333
of 3,601 outputs
Outputs of similar age
#152,126
of 301,533 outputs
Outputs of similar age from Pediatric Nephrology
#34
of 77 outputs
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We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.