| Title |
Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study
|
|---|---|
| Published in |
Brain Imaging and Behavior, March 2016
|
| DOI | 10.1007/s11682-016-9544-3 |
| Pubmed ID | |
| Authors |
Yangding Li, Kai Yuan, Yanzhi Bi, Yanyan Guan, Jiadong Cheng, Yajuan Zhang, Sha Shi, Xiaoqi Lu, Dahua Yu, Jie Tian |
| Abstract |
Studying the neural correlates of craving to smoke in young adulthood is of great importance to improve treatment outcomes in nicotine dependence. Previous nicotine dependence studies mainly focused on the neural substrates of craving elicited by smoking-related cues. More explicit attention to abstinence-induced craving during resting state in nicotine dependence has the potential to yield valuable information about craving, and characterizing this kind of craving is critical for developing effective interventions. Twenty-five young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare regional homogeneity (ReHo) between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers. Then, the ReHo changes associated with smoking abstinence (compared with satiety) were further examined for correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (compared with satiety) had higher ReHo in brain regions in fronto-striatal circuits including bilateral caudate, anterior cingulate cortex (ACC) and bilateral dorsal lateral prefrontal cortex (DLPFC), as well as brain regions in default mode network (DMN) including posterior cingulate cortex (PCC)/precuneus and angular gyrus. Additionally, we found the ReHo changes of the ACC and the bilateral caudate were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on spontaneous brain activity and may contribute new insights into the neural mechanism of abstinence-induced craving in nicotine dependence. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Romania | 1 | 3% |
| Unknown | 38 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Master | 7 | 18% |
| Student > Ph. D. Student | 4 | 10% |
| Student > Bachelor | 4 | 10% |
| Professor > Associate Professor | 3 | 8% |
| Other | 3 | 8% |
| Unknown | 10 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 10 | 26% |
| Neuroscience | 9 | 23% |
| Medicine and Dentistry | 6 | 15% |
| Nursing and Health Professions | 2 | 5% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2016.
All research outputs
#15,364,458
of 22,856,968 outputs
Outputs from Brain Imaging and Behavior
#671
of 1,155 outputs
Outputs of similar age
#179,241
of 299,781 outputs
Outputs of similar age from Brain Imaging and Behavior
#17
of 30 outputs
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