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Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Overview of attention for article published in Genes & Development, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

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1 blog
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4 X users

Citations

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69 Dimensions

Readers on

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76 Mendeley
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Title
Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Published in
Genes & Development, March 2016
DOI 10.1101/gad.275529.115
Pubmed ID
Authors

Nicolas Reynoird, Pawel K. Mazur, Timo Stellfeld, Natasha M. Flores, Shane M. Lofgren, Scott M. Carlson, Elisabeth Brambilla, Pierre Hainaut, Ewa B. Kaznowska, Cheryl H. Arrowsmith, Purvesh Khatri, Carlo Stresemann, Or Gozani, Julien Sage

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND domain 2) are elevated in PDAC and that genetic and pharmacological inhibition of SMYD2 restricts PDAC growth. We further identified the stress response kinase MAPKAPK3 (MK3) as a new physiologic substrate of SMYD2 in PDAC cells. Inhibition of MAPKAPK3 impedes PDAC growth, identifying a potential new kinase target in PDAC. Finally, we show that inhibition of SMYD2 cooperates with standard chemotherapy to treat PDAC cells and tumors. These findings uncover a pivotal role for SMYD2 in promoting pancreatic cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 30%
Researcher 13 17%
Student > Master 7 9%
Student > Bachelor 4 5%
Student > Postgraduate 4 5%
Other 15 20%
Unknown 10 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 39%
Medicine and Dentistry 11 14%
Chemistry 8 11%
Agricultural and Biological Sciences 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 7%
Unknown 14 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2017.
All research outputs
#3,420,662
of 23,577,654 outputs
Outputs from Genes & Development
#1,127
of 5,881 outputs
Outputs of similar age
#60,644
of 328,610 outputs
Outputs of similar age from Genes & Development
#28
of 58 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,881 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,610 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.