| Title |
Caries-preventive effect of anti-erosive and nano-hydroxyapatite-containing toothpastes in vitro
|
|---|---|
| Published in |
Clinical Oral Investigations, March 2016
|
| DOI | 10.1007/s00784-016-1789-0 |
| Pubmed ID | |
| Authors |
M. Esteves-Oliveira, N. M. Santos, H. Meyer-Lueckel, R. J. Wierichs, J. A. Rodrigues |
| Abstract |
The aim of the study was to investigate the caries-preventive effect of newly developed fluoride and fluoride-free toothpastes specially designed for erosion prevention. The hypothesis was that these products might also show superior caries-inhibiting effect than regular fluoride toothpastes, since they were designed for stronger erosive acid challenges. Enamel specimens were obtained from bovine teeth and pre-demineralized (pH = 4.95/21 days) to create artificial caries lesions. Baseline mineral loss (ΔZB) and lesion depth (LDB) were determined using transversal microradiography (TMR). Ninety specimens with a median ΔZB (SD) of 6027 ± 1546 vol% × μm were selected and randomly allocated to five groups (n = 18). Treatments during pH-cycling (14 days, 4 × 60 min demineralization/day) were brushing 2×/day with AmF (1400 ppm F(-), anti-caries [AC]); AmF/NaF/SnCl2/Chitosan (700 ppm F(-)/700 ppm F(-)/3500 ppm Sn(2+), anti-erosion [AE1]); NaF/KNO3 (1400 ppm F(-), anti-erosion [AE2]); nano-hydroxyapatite-containing (0 ppm F(-), [nHA]); and fluoride-free toothpastes (0 ppm F(-), negative control [NC]). Toothpaste slurries were prepared with mineral salt solution (1:3 wt/wt). After pH-cycling specimens presenting lesion, surface loss (mainly by NC and nHA) were discarded. For the remaining 77 specimens, new TMR analyses (ΔZE/LDE) were performed. Changes in mineral loss (ΔΔZ = ΔZB - ΔZE) and lesion depth (ΔLD = LDB - LDE) were calculated. All toothpastes caused significantly less demineralization (lower ΔΔZ) than NC (p < 0.05, ANOVA) except for nHA. The fluoride toothpastes did not differ significantly regarding ΔΔZ and ΔLD (p > 0.05, ANOVA). While both anti-erosive and anti-caries toothpastes reduced mineral loss to a similar extent, the fluoride-free nano-hydroxyapatite-containing toothpaste seemed not to be suitable for inhibition of caries demineralization in vitro. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 33% |
| Latvia | 1 | 33% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | 1% |
| Unknown | 70 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 14% |
| Researcher | 5 | 7% |
| Student > Postgraduate | 5 | 7% |
| Student > Ph. D. Student | 5 | 7% |
| Student > Doctoral Student | 5 | 7% |
| Other | 12 | 17% |
| Unknown | 29 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 37% |
| Chemistry | 3 | 4% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Social Sciences | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 29 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2018.
All research outputs
#3,678,856
of 22,856,968 outputs
Outputs from Clinical Oral Investigations
#104
of 1,409 outputs
Outputs of similar age
#58,430
of 299,781 outputs
Outputs of similar age from Clinical Oral Investigations
#3
of 62 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,409 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.