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Vitamin-D status is not a confounder of the relationship between zinc and diarrhoea: a study in 6–24-month-old underweight and normal-weight children of urban Bangladesh

Overview of attention for article published in European Journal of Clinical Nutrition, March 2016
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Title
Vitamin-D status is not a confounder of the relationship between zinc and diarrhoea: a study in 6–24-month-old underweight and normal-weight children of urban Bangladesh
Published in
European Journal of Clinical Nutrition, March 2016
DOI 10.1038/ejcn.2016.7
Pubmed ID
Authors

A M S Ahmed, R J S Magalhaes, T Ahmed, K Z Long, MdI Hossain, M M Islam, M Mahfuz, S M A Gaffar, A Sharmeen, R Haque, R L Guerrant, W A Petri, A A Mamun

Abstract

The role of micronutrients particularly zinc in childhood diarrhoea is well established. Immunomodulatory functions of vitamin-D in diarrhoea and its role in the effect of other micronutrients are not well understood. This study aimed to investigate whether vitamin-D directly associated or confounded the association between other micronutrient status and diarrhoeal incidence and severity in 6-24-month underweight and normal-weight children in urban Bangladesh. Multivariable generalised estimating equations were used to estimate incidence rate ratios for incidence (Poisson) and severity (binomial) of diarrhoea on cohorts of 446 normal-weight and 466 underweight children. Outcomes of interest included incidence and severity of diarrhoea, measured daily during a follow-up period of 5 months. The exposure of interest was vitamin-D status at enrolment. Normal-weight and underweight children contributed 62 117 and 62 967 day observation, with 14.2 and 12.8 days/child/year of diarrhoea, respectively. None of the models showed significant associations of vitamin-D status with diarrhoeal morbidity. In the final model, zinc-insufficient normal-weight children had 1.3 times more days of diarrhoea than sufficient children (P<0.05). Again zinc insufficiency and mother's education (1-5 and >5 years) had 1.8 and 2.3 times more risk of severe diarrhoea. In underweight children, older age and female had 24-63 and 17% fewer days of diarrhoea and 52-54 and 31% fewer chances of severe diarrhoea. Vitamin-D status was not associated with incidence and severity of diarrhoea in study children. Role of zinc in diarrhoea was only evident in normal-weight children. Our findings demonstrate that vitamin-D is not a confounder of the relationship between zinc and diarrhoea.European Journal of Clinical Nutrition advance online publication, 9 March 2016; doi:10.1038/ejcn.2016.7.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 17%
Student > Master 9 16%
Student > Ph. D. Student 6 10%
Student > Doctoral Student 3 5%
Student > Bachelor 2 3%
Other 6 10%
Unknown 22 38%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Nursing and Health Professions 6 10%
Social Sciences 6 10%
Agricultural and Biological Sciences 2 3%
Immunology and Microbiology 2 3%
Other 8 14%
Unknown 23 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2018.
All research outputs
#15,268,080
of 24,677,985 outputs
Outputs from European Journal of Clinical Nutrition
#3,037
of 4,017 outputs
Outputs of similar age
#158,766
of 305,569 outputs
Outputs of similar age from European Journal of Clinical Nutrition
#51
of 60 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,017 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,569 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.