Title |
The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems
|
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Published in |
International Journal of Pharmaceutics, March 2016
|
DOI | 10.1016/j.ijpharm.2016.03.023 |
Pubmed ID | |
Authors |
Katarzyna Gniado, Korbinian Löbmann, Thomas Rades, Andrea Erxleben |
Abstract |
A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-formers stabilize the amorphous state during storage, only co-amorphization with NaTC provides a dissolution advantage over crystalline SMZ and the reasons for this were analyzed. In the case of SMZ/DA extensive gelation of DA protects the amorphous phase from crystallization upon contact with buffer, but at the same time prevents the release of SMZ into solution. Disk dissolution studies showed an improved dissolution behavior of SMZ/CA compared to crystalline SMZ. However, enhanced dissolution properties were not seen in powder dissolution testing due to poor dispersibility. Co-amorphization of SMZ and NaTC resulted in a significant increase in dissolution rate, both in powder and disk dissolution studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 22% |
Student > Bachelor | 7 | 14% |
Student > Master | 5 | 10% |
Student > Postgraduate | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Other | 6 | 12% |
Unknown | 14 | 28% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 19 | 38% |
Chemistry | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Chemical Engineering | 1 | 2% |
Other | 4 | 8% |
Unknown | 16 | 32% |