| Title |
A respiratory syncytial virus persistent-infected cell line system reveals the involvement of SOCS1 in the innate antiviral response
|
|---|---|
| Published in |
Virologica Sinica, June 2015
|
| DOI | 10.1007/s12250-015-3597-0 |
| Pubmed ID | |
| Authors |
Junwen Zheng, Pu Yang, Yan Tang, Dongchi Zhao |
| Abstract |
HEp-2 cells persistently infected with respiratory syncytial virus (RSV) are a heterogeneous mixture of viral antigen-positive and -negative variants; however, the mechanism through which viral replication becomes latent remains unclear. In this study, we investigated the potential mechanism by which RSV escapes from innate immune surveillance. Persistent-infected RSV HEp-2 cells were isolated and cell clones were passaged. The RSV-persistent cells produced viruses at a lower titer, resisted wild-type RSV re-infection, and secreted high levels of interferon-ß (IFN-ß), macrophage inflammatory protein-1α (Mip-1α), interleukin-8 (IL-8), and Rantes. Toll-like receptor 3 (TLR3), retinoic acid inducible gene-I (RIG-I), and suppressor of cytokine signaling 1 (SOCS1) levels were upregulated in these cells. The silencing of TLR3 mRNA decreased the expression of SOCS1 protein and the secretion of cytokines. RSV-persistent cells are in an inflammatory state; upregulation of SOCS1 is related to the TLR3 signaling pathway, which could be associated with the mechanism of viral persistence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 8 | 35% |
| Student > Master | 5 | 22% |
| Researcher | 5 | 22% |
| Professor | 1 | 4% |
| Other | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 4 | 17% |
| Immunology and Microbiology | 4 | 17% |
| Business, Management and Accounting | 3 | 13% |
| Agricultural and Biological Sciences | 3 | 13% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Other | 2 | 9% |
| Unknown | 5 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2016.
All research outputs
#20,315,221
of 22,856,968 outputs
Outputs from Virologica Sinica
#433
of 572 outputs
Outputs of similar age
#220,479
of 264,738 outputs
Outputs of similar age from Virologica Sinica
#5
of 8 outputs
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