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Mendeley readers
Attention Score in Context
| Title |
Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 2016
|
| DOI | 10.1073/pnas.1525790113 |
| Pubmed ID | |
| Authors |
Helena Safavi-Hemami, Qing Li, Ronneshia L Jackson, Albert S Song, Wouter Boomsma, Pradip K Bandyopadhyay, Christian W Gruber, Anthony W Purcell, Mark Yandell, Baldomero M Olivera, Lars Ellgaard |
| Abstract |
Formation of correct disulfide bonds in the endoplasmic reticulum is a crucial step for folding proteins destined for secretion. Protein disulfide isomerases (PDIs) play a central role in this process. We report a previously unidentified, hypervariable family of PDIs that represents the most diverse gene family of oxidoreductases described in a single genus to date. These enzymes are highly expressed specifically in the venom glands of predatory cone snails, animals that synthesize a remarkably diverse set of cysteine-rich peptide toxins (conotoxins). Enzymes in this PDI family, termed conotoxin-specific PDIs, significantly and differentially accelerate the kinetics of disulfide-bond formation of several conotoxins. Our results are consistent with a unique biological scenario associated with protein folding: The diversification of a family of foldases can be correlated with the rapid evolution of an unprecedented diversity of disulfide-rich structural domains expressed by venomous marine snails in the superfamily Conoidea. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 19% |
| Student > Ph. D. Student | 13 | 15% |
| Researcher | 12 | 14% |
| Student > Master | 12 | 14% |
| Professor | 4 | 5% |
| Other | 13 | 15% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 31% |
| Agricultural and Biological Sciences | 25 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Chemistry | 4 | 5% |
| Engineering | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 18 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2020.
All research outputs
#8,219,054
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#64,491
of 101,438 outputs
Outputs of similar age
#109,386
of 304,824 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#673
of 883 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,824 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 883 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.