| Title |
Poorly differentiated clusters (PDC) in colorectal cancer: what is and ought to be known
|
|---|---|
| Published in |
Diagnostic Pathology, March 2016
|
| DOI | 10.1186/s13000-016-0481-7 |
| Pubmed ID | |
| Authors |
Luca Reggiani Bonetti, Valeria Barresi, Stefania Bettelli, Federica Domati, Cristian Palmiere |
| Abstract |
The counting of poorly differentiated clusters of 5 or more cancer cells lacking a gland-like structure in a tumor mass has recently been identified among the histological features predictive of poor prognosis in colorectal cancer. Poorly differentiated clusters can easily be recognized in the histological sections of colorectal cancer routinely stained with haematoxylin and eosin. Despite some limitations related to specimen fragmentation, counting can also be assessed in endoscopic biopsies. Based on the number of poorly differentiated clusters that appear under a microscopic field of a ×20 objective lens (i.e., a microscopic field with a major axis of 1 mm), colorectal cancer can be graded into malignancies as follows: tumors with <5 clusters as grade 1, tumors with 5 to 9 clusters as grade 2, and tumors with ≥10 clusters as grade 3. High poorly differentiated cluster counts are significantly associated with peri-neural and lympho-vascular invasion, the presence of nodal metastases or micrometastases, as well as shorter overall and progression free survival to colorectal cancer. The morphological aspects and clinical relevance of poorly differentiated clusters counting in colorectal cancer are discussed in this review. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 38% |
| Brazil | 2 | 25% |
| Venezuela, Bolivarian Republic of | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 4 | 50% |
| Members of the public | 3 | 38% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 72 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Student > Bachelor | 11 | 15% |
| Other | 9 | 12% |
| Researcher | 8 | 11% |
| Student > Doctoral Student | 7 | 9% |
| Other | 13 | 18% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 57% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Agricultural and Biological Sciences | 3 | 4% |
| Immunology and Microbiology | 2 | 3% |
| Arts and Humanities | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 14 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#6,571,725
of 25,373,627 outputs
Outputs from Diagnostic Pathology
#145
of 1,193 outputs
Outputs of similar age
#87,366
of 314,387 outputs
Outputs of similar age from Diagnostic Pathology
#4
of 17 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,193 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,387 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.