| Title |
Aging, inflammation, stem cells, and bone healing
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2016
|
| DOI | 10.1186/s13287-016-0300-9 |
| Pubmed ID | |
| Authors |
Emmanuel Gibon, Laura Lu, Stuart B. Goodman |
| Abstract |
Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone healing. Whereas the former lineage directs inflammatory events and bone resorption, the latter represents a source of cells for bone regeneration and immune modulation. Both of these lineages are affected by increasing age, which is associated with higher baseline levels of inflammatory mediators, and a significant reduction in osteogenic capabilities. Given the above, fracture healing, osteoporosis, and other related events in the elderly present numerous challenges, which potentially could be aided by new therapeutic approaches to modulate both inflammation and bone regeneration. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| Ecuador | 1 | 11% |
| United Kingdom | 1 | 11% |
| Belgium | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 232 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 15% |
| Researcher | 32 | 14% |
| Student > Master | 31 | 13% |
| Student > Bachelor | 29 | 12% |
| Student > Doctoral Student | 13 | 6% |
| Other | 41 | 18% |
| Unknown | 52 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 71 | 30% |
| Biochemistry, Genetics and Molecular Biology | 35 | 15% |
| Agricultural and Biological Sciences | 22 | 9% |
| Engineering | 11 | 5% |
| Veterinary Science and Veterinary Medicine | 6 | 3% |
| Other | 24 | 10% |
| Unknown | 64 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2022.
All research outputs
#2,163,466
of 25,630,321 outputs
Outputs from Stem Cell Research & Therapy
#134
of 2,781 outputs
Outputs of similar age
#34,446
of 314,998 outputs
Outputs of similar age from Stem Cell Research & Therapy
#6
of 37 outputs
Altmetric has tracked 25,630,321 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,781 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.