Although it is well established that funding source influences the publication of clinical trials, relatively little is known about how funding influences trial design. We examined a public trial registry to determine how funding source shapes trial design among trials involving antihyperlipidemics. We used an automated process to identify and analyze 809 trials from a set of 72,564. Three networks representing industry-, collaboratively, and non-industry-funded trials were constructed. Each network comprised 18 drugs as nodes connected according to the number of comparisons made between them. The results indicated that industry-funded trials were more likely to compare across drugs and examine dyslipidemia as a condition, and less likely to register safety outcomes. The source of funding for clinical trials had a measurable effect on trial design, which helps quantify differences in research agendas. Improved monitoring of current clinical trials may be used to more closely align research agendas to clinical needs.
Pharmacology, Toxicology and Pharmaceutical Science
2
7%
Agricultural and Biological Sciences
2
7%
Economics, Econometrics and Finance
2
7%
Social Sciences
2
7%
Other
5
19%
Unknown
3
11%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2014.
All research outputs
#26,351,586
of 32,973,893 outputs
Outputs from Clinical Pharmacology & Therapeutics
#4,916
of 5,628 outputs
Outputs of similar age
#156,315
of 195,297 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#45
of 54 outputs
Altmetric has tracked 32,973,893 research outputs across all sources so far. This one is in the 17th percentile – i.e., 17% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,628 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,297 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
