Title |
The Role and Impact of Research Agendas on the Comparative‐Effectiveness Research Among Antihyperlipidemics
|
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Published in |
Clinical Pharmacology & Therapeutics, February 2012
|
DOI | 10.1038/clpt.2011.279 |
Pubmed ID | |
Authors |
A G Dunn, F T Bourgeois, S Murthy, K D Mandl, R O Day, E Coiera |
Abstract |
Although it is well established that funding source influences the publication of clinical trials, relatively little is known about how funding influences trial design. We examined a public trial registry to determine how funding source shapes trial design among trials involving antihyperlipidemics. We used an automated process to identify and analyze 809 trials from a set of 72,564. Three networks representing industry-, collaboratively, and non-industry-funded trials were constructed. Each network comprised 18 drugs as nodes connected according to the number of comparisons made between them. The results indicated that industry-funded trials were more likely to compare across drugs and examine dyslipidemia as a condition, and less likely to register safety outcomes. The source of funding for clinical trials had a measurable effect on trial design, which helps quantify differences in research agendas. Improved monitoring of current clinical trials may be used to more closely align research agendas to clinical needs. |
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United Kingdom | 1 | 25% |
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Members of the public | 1 | 25% |
Unknown | 1 | 25% |
Mendeley readers
Geographical breakdown
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United States | 2 | 7% |
Australia | 1 | 3% |
Unknown | 26 | 90% |
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Researcher | 8 | 28% |
Student > Master | 4 | 14% |
Librarian | 2 | 7% |
Student > Bachelor | 2 | 7% |
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Unknown | 4 | 14% |
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Economics, Econometrics and Finance | 2 | 7% |
Other | 6 | 21% |
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