Title |
Standardized mental stress in healthy volunteers induced by delayed auditory feedback (DAF)
|
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Published in |
European Journal of Clinical Pharmacology, May 1979
|
DOI | 10.1007/bf00562057 |
Pubmed ID | |
Authors |
M. Badian, E. Appel, D. Palm, W. Rupp, W. Sittig, K. Taeuber |
Abstract |
Using delayed auditory feedback (delay 0.175 s) a standardized form of mental stress was investigated in 8 healthy male volunteers. After a resting period and a period of undelayed reading, the volunteers were exposed for 5 min to the DAF stress. During the DAF period heart rate increased by 10% and systolic and diastolic blood pressure increased by 9% and 18%, respectively. As a measure of acute sympathetic activation, plasma concentrations of norepinephrine and epinephrine rose by 68% and 49%, respectively. The activity od dopamine-beta-hydroxylase in plasma was increased by 25%. From these results it can be concluded that the DAF procedure provides a suitable method for inducing a standardized mental stress in normal subjects, which can be measured as changes in biochemical and cardiovascular variables. |
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