| Title |
Microvascular Dysfunction and Cognitive Impairment
|
|---|---|
| Published in |
Cellular and Molecular Neurobiology, March 2016
|
| DOI | 10.1007/s10571-015-0308-1 |
| Pubmed ID | |
| Authors |
T. Michael De Silva, Frank M. Faraci |
| Abstract |
The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral vasculature is critical for proper cognitive performance. The cerebral microvasculature is a key site of vascular resistance and a preferential target for small vessel disease. While deleterious effects of vascular risk factors on microvascular function are known, the contribution of this dysfunction to cognitive deficits is less clear. In this review, we summarize current evidence for microvascular dysfunction in brain. We highlight effects of select vascular risk factors (hypertension, diabetes, and hyperhomocysteinemia) on the pial and parenchymal circulation. Lastly, we discuss potential links between microvascular disease and cognitive function, highlighting current gaps in our understanding. |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 131 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 14% |
| Student > Ph. D. Student | 17 | 13% |
| Student > Bachelor | 12 | 9% |
| Professor > Associate Professor | 11 | 8% |
| Student > Master | 9 | 7% |
| Other | 26 | 20% |
| Unknown | 39 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 19% |
| Neuroscience | 21 | 16% |
| Agricultural and Biological Sciences | 8 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Nursing and Health Professions | 5 | 4% |
| Other | 21 | 16% |
| Unknown | 46 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
All research outputs
#7,916,538
of 23,854,458 outputs
Outputs from Cellular and Molecular Neurobiology
#359
of 1,046 outputs
Outputs of similar age
#118,685
of 330,472 outputs
Outputs of similar age from Cellular and Molecular Neurobiology
#24
of 54 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,046 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.