| Title |
On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools
|
|---|---|
| Published in |
Transgenic Research, March 2012
|
| DOI | 10.1007/s11248-012-9599-x |
| Pubmed ID | |
| Authors |
V. Duranthon, N. Beaujean, M. Brunner, K. E. Odening, A. Navarrete Santos, I. Kacskovics, L. Hiripi, E. J. Weinstein, Z. Bosze |
| Abstract |
The laboratory rabbit (Oryctolagus cuniculus) is widely used as a model for human diseases, because of its size, which permits non-lethal monitoring of physiological changes and similar disease characteristics. Novel transgenic tools such as, the zinc finger nuclease method and the sleeping beauty transposon mediated or BAC transgenesis were recently adapted to the laboratory rabbit and opened new opportunities in precise tissue and developmental stage specific gene expression/silencing, coupled with increased transgenic efficiencies. Many facets of human development and diseases cannot be investigated in rodents. This is especially true for early prenatal development, its long-lasting effects on health and complex disorders, and some economically important diseases such as atherosclerosis or cardiovascular diseases. The first transgenic rabbits models of arrhythmogenesis mimic human cardiac diseases much better than transgenic mice and hereby underline the importance of non-mouse models. Another emerging field is epigenetic reprogramming and pathogenic mechanisms in diabetic pregnancy, where rabbit models are indispensable. Beyond that rabbit is used for decades as major source of polyclonal antibodies and recently in monoclonal antibody production. Alteration of its genome to increase the efficiency and value of the antibodies by humanization of the immunoglobulin genes, or by increasing the expression of a special receptor (Fc receptor) that augments humoral immune response is a current demand. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Brazil | 1 | 25% |
| Australia | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 3% |
| Netherlands | 1 | 1% |
| New Zealand | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 65 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 25% |
| Researcher | 16 | 23% |
| Student > Bachelor | 11 | 15% |
| Student > Master | 8 | 11% |
| Professor > Associate Professor | 4 | 6% |
| Other | 8 | 11% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 48% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Medicine and Dentistry | 9 | 13% |
| Nursing and Health Professions | 3 | 4% |
| Neuroscience | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 6 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2012.
All research outputs
#13,863,864
of 22,663,150 outputs
Outputs from Transgenic Research
#685
of 889 outputs
Outputs of similar age
#91,164
of 156,014 outputs
Outputs of similar age from Transgenic Research
#7
of 11 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 889 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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