| Title |
Antidepressant-Like Effect of Ropren® in β-Amyloid-(25–35) Rat Model of Alzheimer’s Disease with Altered Levels of Androgens
|
|---|---|
| Published in |
Molecular Neurobiology, March 2016
|
| DOI | 10.1007/s12035-016-9848-8 |
| Pubmed ID | |
| Authors |
Vagif Soultanov, Julia Fedotova, Tamara Nikitina, Victor Roschin, Natalia Ordyan, Lucian Hritcu |
| Abstract |
This study elucidated the potential antidepressant-like effect of prolonged Ropren® administration (8.6 mg/kg, orally, once daily for 28 days) using a β-amyloid (25-35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25-35) into gonadectomized (GDX) rats and GDX rats with testosterone propionate (TP, 0.5 mg/kg, subcutaneous, once daily, 28 days) supplementation. Ropren® was administered to the GDX rats and GDX rats treated with TP. Depression-like behavior was assessed in the forced swimming test, and the spontaneous locomotor activity was assessed using the open-field test. The corticosterone and testosterone levels in the blood serum before and after FST were measured in all experimental groups. Treatment with Ropren® significantly decreased the immobility time of GDX rats with β-amyloid (25-35) in the forced swimming test. Coadministration of Ropren® with TP exerted a markedly synergistic antidepressant-like effect in the GDX rats with β-amyloid (25-35 on the same model of depression-like behavior testing. Ropren® administered alone or together with TP significantly enhanced crossing, frequency of rearing, and grooming of the GDX rats with β-amyloid (25-35) in the open-field test. Moreover, Ropren® administered alone or together with TP significantly decreased the elevated corticosterone levels in the blood serum of GDX rats with β-amyloid (25-35) following the forced swimming test. These results indicate that Ropren® has a marked antidepressant-like effect in the experimental model of Alzheimer's disease in male rats with altered levels of androgens. |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 21% |
| Student > Bachelor | 9 | 17% |
| Student > Doctoral Student | 4 | 8% |
| Student > Ph. D. Student | 4 | 8% |
| Lecturer | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 7 | 13% |
| Neuroscience | 6 | 12% |
| Nursing and Health Professions | 4 | 8% |
| Medicine and Dentistry | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 19 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2016.
All research outputs
#4,185,991
of 22,858,915 outputs
Outputs from Molecular Neurobiology
#869
of 3,461 outputs
Outputs of similar age
#65,465
of 299,781 outputs
Outputs of similar age from Molecular Neurobiology
#42
of 130 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,461 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.