Title |
Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility‐weighted imaging in idiopathic rapid eye movement sleep behavior disorder
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Published in |
Annals of Neurology, April 2016
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DOI | 10.1002/ana.24646 |
Pubmed ID | |
Authors |
Roberto De Marzi, Klaus Seppi, Birgit Högl, Christoph Müller, Christoph Scherfler, Ambra Stefani, Alex Iranzo, Eduardo Tolosa, Joan Santamarìa, Elke Gizewski, Michael Schocke, Elisabeth Skalla, Christian Kremser, Werner Poewe |
Abstract |
We assessed loss of dorsolateral nigral hyperintensity (DNH) on high-field susceptibility-weighted imaging (SWI), a novel MRI marker for Parkinson's Disease (PD), in 15 subjects with idiopathic REM sleep behavior disorder (iRBD) and compared findings to 42 healthy controls (HC) and 104 PD patients. We found loss of DNH in at least two thirds of iRBD subjects, which approaches the rate seen in PD and is in contrast to findings in HC. We propose that absence of DNH on high-field SWI could identify prodromal degenerative parkinsonism in iRBD. This article is protected by copyright. All rights reserved. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Colombia | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 107 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 15% |
Student > Master | 14 | 13% |
Researcher | 13 | 12% |
Other | 8 | 7% |
Student > Doctoral Student | 5 | 5% |
Other | 18 | 17% |
Unknown | 33 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 23% |
Neuroscience | 16 | 15% |
Psychology | 6 | 6% |
Nursing and Health Professions | 4 | 4% |
Agricultural and Biological Sciences | 3 | 3% |
Other | 10 | 9% |
Unknown | 43 | 40% |