Title |
Comprehensive Physiology
|
---|---|
Published in |
Comprehensive Physiology, January 2016
|
DOI | 10.1002/cphy.c150002 |
Pubmed ID | |
Authors |
Steyn, Frederik J., Tolle, Virginie, Chen, Chen, Epelbaum, Jacques |
Abstract |
This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging. © 2016 American Physiological Society. Compr Physiol 6:687-735, 2016. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 124 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 11% |
Student > Bachelor | 14 | 11% |
Student > Doctoral Student | 12 | 10% |
Researcher | 11 | 9% |
Other | 10 | 8% |
Other | 31 | 25% |
Unknown | 32 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 19% |
Agricultural and Biological Sciences | 20 | 16% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Neuroscience | 9 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 17 | 14% |
Unknown | 37 | 30% |