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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
|
|---|---|
| Published in |
Nature Medicine, March 2016
|
| DOI | 10.1038/nm.4070 |
| Pubmed ID | |
| Authors |
Junjian Wang, June X Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C Yang, Maggie C Louie, Alexander D Borowsky, Allen C Gao, Christopher P Evans, Kit S Lam, Jianzhen Xu, Hsing-Jien Kung, Ronald M Evans, Yong Xu, Hong-Wu Chen |
| Abstract |
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoic acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in metastatic CRPC tumors, and that ROR-γ drives AR expression in the tumors. ROR-γ recruits nuclear receptor coactivator 1 and 3 (NCOA1 and NCOA3, also known as SRC-1 and SRC-3) to an AR-ROR response element (RORE) to stimulate AR gene transcription. ROR-γ antagonists suppress the expression of both AR and its variant AR-V7 in prostate cancer (PCa) cell lines and tumors. ROR-γ antagonists also markedly diminish genome-wide AR binding, H3K27ac abundance and expression of the AR target gene network. Finally, ROR-γ antagonists suppressed tumor growth in multiple AR-expressing, but not AR-negative, xenograft PCa models, and they effectively sensitized CRPC tumors to enzalutamide, without overt toxicity, in mice. Taken together, these results establish ROR-γ as a key player in CRPC by acting upstream of AR and as a potential therapeutic target for advanced PCa. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 42% |
| United Kingdom | 1 | 8% |
| Saudi Arabia | 1 | 8% |
| New Zealand | 1 | 8% |
| Peru | 1 | 8% |
| Unknown | 3 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 50% |
| Scientists | 3 | 25% |
| Practitioners (doctors, other healthcare professionals) | 2 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | <1% |
| Uruguay | 1 | <1% |
| Finland | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 160 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 20% |
| Student > Ph. D. Student | 29 | 18% |
| Student > Bachelor | 16 | 10% |
| Student > Master | 13 | 8% |
| Other | 10 | 6% |
| Other | 31 | 19% |
| Unknown | 33 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 21% |
| Agricultural and Biological Sciences | 31 | 19% |
| Medicine and Dentistry | 30 | 18% |
| Chemistry | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 14 | 8% |
| Unknown | 41 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 196. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2022.
All research outputs
#194,903
of 24,857,051 outputs
Outputs from Nature Medicine
#790
of 9,098 outputs
Outputs of similar age
#3,485
of 307,151 outputs
Outputs of similar age from Nature Medicine
#8
of 69 outputs
Altmetric has tracked 24,857,051 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,098 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 104.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.