Contemporary Biostatistics with Biopharmaceutical Applications

Chapter 1 Nonparametric Inference on Tumor Incidence with Partially Identified Cause-of-Death Data

Chapter 2 Variable Selection for High Dimensional Metagenomic Data

Chapter 3 Dimension Reduction in High Dimensional Multivariate Time Series Analysis

Chapter 4 A Powerful Retrospective Multiple Variant Association Test for Quantitative Traits by Borrowing Strength from Complex Genotypic Correlations

Chapter 5 Inference of Gene Regulatory Network Through Adaptive Dynamic Bayesian Network Modeling

Chapter 6 Maximin Designs for Ultra-Fast Functional Brain Imaging

Chapter 7 A Global Optimization Algorithm for Sparse Mixed Membership Matrix Factorization

Chapter 8 A Nonnegative Robust Linear Model for Deconvolution of Proportions

Chapter 9 Practical Design Approaches for Assessing Parallelism in Dose Response Modelling

Chapter 10 Optimal Adaptive Phase III Design with Interim Sample Size and Dose Determination

Chapter 11 Critical Boundary Refinement in a Group Sequential Trial When the Primary Endpoint Data Accumulate Faster Than the Secondary Endpoint

Chapter 12 Bayesian Dose Escalation Study Design with Consideration of Both Early and Late Onset Toxicity

Chapter 13 A Bayesian Constancy-Enforced Non-Inferiority Design in Medical Device Trials with a Binary Endpoint

Chapter 14 Adaptive Randomization for Master Protocols in Precision Medicine

Chapter 15 Some Statistical Considerations in Design and Analysis for Nonrandomized Comparative Studies Using Existing Data as Controls for Medical Device Premarket Evaluation

Chapter 16 Review of Statistical Issues in Pragmatic Clinical Trials in Current Drug Development Environment

Chapter 17 Evaluating Potential Subpopulations Using Stochastic SIDEScreen in a Cross-Over Trial

Chapter 18 What Is the Right Comparison? ROC Curve and Trade-Off Between Key Diagnostic Test Errors (ROCKE)