| Title |
Morning Home Blood Pressure Is a Strong Predictor of Coronary Artery Disease The HONEST Study
|
|---|---|
| Published in |
JACC, April 2016
|
| DOI | 10.1016/j.jacc.2016.01.037 |
| Pubmed ID | |
| Authors |
Kazuomi Kario, Ikuo Saito, Toshio Kushiro, Satoshi Teramukai, Yasuhiro Tomono, Yasuyuki Okuda, Kazuyuki Shimada |
| Abstract |
Few studies have evaluated out-of-office blood pressure (BP) measurements as predictors of coronary artery disease (CAD) events. The aim of this study was to determine morning home blood pressure (HBP) as a predictor of CAD events. Using data from the HONEST (Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure) study, we investigated the relationship between morning HBP and incidence of stroke and CAD events. In 21,591 treated hypertensive patients (mean age 64.9 years; mean follow-up 2.02 years), 127 stroke events (2.92 per 1,000 patient-years), and 121 CAD events (2.78 per 1,000 patient-years) occurred. The incidence of stroke events was significantly higher in patients with morning home systolic blood pressure (HSBP) ≥145 mm Hg compared with <125 mm Hg, and in patients with clinic systolic blood pressure (CSBP) ≥150 mm Hg compared with <130 mm Hg. Hazard ratios (HRs) were 6.01 (95% confidence interval [CI]: 2.85 to 12.68) between patients with morning HSBP ≥155 mm Hg and those with morning HSBP <125 mm Hg and 5.82 (95% CI: 3.17 to 10.67) between patients with CSBP ≥160 mm Hg and those with CSBP <130 mm Hg; morning HSBP predicted stroke events similarly to CSBP. Incidence of CAD events was significantly higher in patients with morning HSBP ≥145 mm Hg compared with <125 mm Hg and in patients with CSBP ≥160 mm Hg compared with <130 mm Hg. The HR for morning HSBP ≥155 mm Hg was 6.24 (95% CI: 2.82 to 13.84) and for CSBP ≥160 mm Hg was 3.51 (95% CI: 1.71 to 7.20); therefore, compared with morning HSBP, CSBP may underestimate CAD risk. Goodness-of-fit analysis showed that morning HSBP predicted CAD events more strongly than CSBP. Morning HBP is a strong predictor of future CAD and stroke events, and may be superior to clinic BP in this regard. There does not appear to be a J-curve in the relationship between morning HBP and stroke or CAD events. (Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure Study [HONEST]; UMIN000002567). |
X Demographics
The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 21% |
| Spain | 9 | 16% |
| Canada | 3 | 5% |
| Argentina | 2 | 4% |
| Saudi Arabia | 2 | 4% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| United Kingdom | 2 | 4% |
| Mexico | 1 | 2% |
| Ecuador | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 20 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 68% |
| Practitioners (doctors, other healthcare professionals) | 10 | 18% |
| Scientists | 6 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 17% |
| Student > Master | 7 | 13% |
| Other | 6 | 11% |
| Student > Bachelor | 4 | 8% |
| Professor | 4 | 8% |
| Other | 9 | 17% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 43% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Nursing and Health Professions | 4 | 8% |
| Computer Science | 3 | 6% |
| Engineering | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 15 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 130. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2021.
All research outputs
#319,545
of 25,374,647 outputs
Outputs from JACC
#736
of 16,741 outputs
Outputs of similar age
#5,823
of 314,727 outputs
Outputs of similar age from JACC
#18
of 361 outputs
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