| Title |
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
|
|---|---|
| Published in |
Cancer Immunology, Immunotherapy, March 2016
|
| DOI | 10.1007/s00262-016-1826-5 |
| Pubmed ID | |
| Authors |
Fergus Noble, Toby Mellows, Leo H. McCormick Matthews, Adrian C. Bateman, Scott Harris, Timothy J. Underwood, James P. Byrne, Ian S. Bailey, Donna M. Sharland, Jamie J. Kelly, John N. Primrose, Surinder S. Sahota, Andrew R. Bateman, Gareth J. Thomas, Christian H. Ottensmeier |
| Abstract |
Oesophageal adenocarcinoma (OAC) is increasingly common in the west, and survival remains poor at 10-15 % at 5 years. Immune responses are increasingly implicated as a determining factor of tumour progression. The ability of lymphocytes to recognise tumour antigens provides a mechanism for a host immune attack against cancer providing a potential treatment strategy. Tumour infiltrating lymphocytes (TILs: CD3+, CD4+, CD8+ and FOXp3+) were assessed by immunohistochemistry using tissue microarrays in a contemporary and homogeneous cohort of OAC patients (n = 128) undergoing curative treatment. Multivariate analysis identified three independent prognostic factors for improved cancer-specific survival (CSS): increased CD8+ TILs (p = 0.003), completeness of resection (p < 0.0001) and lower pathological N stage (p < 0.0001). Independent prognostic factors for favourable disease-free survival included surgery-only treatment (p = 0.015), completeness of resection (p = 0.001), increased CD8+ TILs (p < 0.0001) and reduced pathological N stage (p < 0.0001). Higher levels of TILs in the pathological specimen were associated with significant pathological response to neoadjuvant chemotherapy (NAC). On multivariate analysis increased levels of CD4+ (p = 0.017) and CD8+ TILs (p = 0.005) were associated with significant local tumour regression and lymph node downstaging, respectively. Our results establish an association of TILs and survival in OAC, as seen in other solid tumours, and identify particular TIL subsets that are present at higher levels in patients who responded to NAC compared to non-responders. These findings highlight potential therapeutic strategies in EAC based on utilising the host immunological response and highlight the immune responses biomarker potential. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Researcher | 13 | 16% |
| Student > Bachelor | 9 | 11% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 4 | 5% |
| Other | 14 | 18% |
| Unknown | 18 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 38% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Immunology and Microbiology | 8 | 10% |
| Agricultural and Biological Sciences | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 20 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2016.
All research outputs
#15,330,390
of 23,577,654 outputs
Outputs from Cancer Immunology, Immunotherapy
#2,113
of 2,948 outputs
Outputs of similar age
#173,035
of 302,851 outputs
Outputs of similar age from Cancer Immunology, Immunotherapy
#20
of 36 outputs
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