Title |
An integrated interface for peripheral neural system recording and stimulation: system design, electrical tests and in-vivo results
|
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Published in |
Biomedical Microdevices, March 2016
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DOI | 10.1007/s10544-016-0043-5 |
Pubmed ID | |
Authors |
Caterina Carboni, Lorenzo Bisoni, Nicola Carta, Roberto Puddu, Stanisa Raspopovic, Xavier Navarro, Luigi Raffo, Massimo Barbaro |
Abstract |
The prototype of an electronic bi-directional interface between the Peripheral Nervous System (PNS) and a neuro-controlled hand prosthesis is presented. The system is composed of 2 integrated circuits: a standard CMOS device for neural recording and a HVCMOS device for neural stimulation. The integrated circuits have been realized in 2 different 0.35μ m CMOS processes available from ams. The complete system incorporates 8 channels each including the analog front-end, the A/D conversion, based on a sigma delta architecture and a programmable stimulation module implemented as a 5-bit current DAC; two voltage boosters supply the output stimulation stage with a programmable voltage scalable up to 17V. Successful in-vivo experiments with rats having a TIME electrode implanted in the sciatic nerve were carried out, showing the capability of recording neural signals in the tens of microvolts, with a global noise of 7μ V r m s , and to selectively elicit the tibial and plantar muscles using different active sites of the electrode. |
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