| Title |
Family history and risk of breast cancer: nurses’ health study
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, February 2012
|
| DOI | 10.1007/s10549-012-1985-9 |
| Pubmed ID | |
| Authors |
Graham A. Colditz, Kimberly A. Kaphingst, Susan E. Hankinson, Bernard Rosner |
| Abstract |
Family history of cancer remains underused in general clinical practice. We assess age at diagnosis and the role of family history in risk of breast cancer. Prospective follow-up of nurses' health study participants from 1980 to 2006. Updated assessment of family history in mother and sister including age at diagnosis. We used youngest age at diagnosis for family member when classifying risk. We confirmed 4327 incident invasive breast cancers confirmed. Breast cancer incidence models fitted to women with and without family history to assess variation in the risk for established risk factors. Compared to women with no family history those whose mother was diagnosed before age 50 had an adjusted relative risk of 1.69 (95% CI 1.39-2.05) and those with mother diagnosed at 50 or older had a relative risk of 1.37 (1.22-1.53). Sister history was associated with increased relative risk; 1.66 (1.38-1.99) for those with sister history before age 50 and 1.52 (1.29-1.77) for those with sister diagnosed at age 50 or older. Women with either mother or sister diagnosed before age 50 had a relative risk of 1.70 (1.48-1.95) significantly higher than those with diagnosis at age 50 or older (RR = 1.30; (1.27-1.54), P = 0.016). The magnitude of risk associated with established reproductive and lifestyle risk factors did not differ significantly between women with and those without family history with the exception of risk after bilateral oophorectomy in which setting women with family history had greater reduction in risk of subsequent breast cancer. Women with a family member diagnosed with breast cancer before age 50 had increased risk of breast cancer compared to women with family members diagnosed at older ages. Consistent findings for risk factors regardless of family history adds to robust evidence for risk identification and risk stratification in clinical settings where prevention strategies will apply equally to women with and without family history. |
Mendeley readers
The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Unknown | 259 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 54 | 21% |
| Student > Ph. D. Student | 31 | 12% |
| Student > Bachelor | 25 | 10% |
| Researcher | 15 | 6% |
| Student > Doctoral Student | 14 | 5% |
| Other | 27 | 10% |
| Unknown | 95 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 21% |
| Biochemistry, Genetics and Molecular Biology | 41 | 16% |
| Nursing and Health Professions | 15 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
| Agricultural and Biological Sciences | 6 | 2% |
| Other | 25 | 10% |
| Unknown | 108 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#2,034,422
of 23,179,757 outputs
Outputs from Breast Cancer Research and Treatment
#286
of 4,697 outputs
Outputs of similar age
#12,199
of 157,237 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#2
of 44 outputs
Altmetric has tracked 23,179,757 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,697 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,237 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.