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Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists

Overview of attention for article published in Histopathology, May 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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2 news outlets
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Title
Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists
Published in
Histopathology, May 2016
DOI 10.1111/his.12976
Pubmed ID
Authors

Charlotte F Kweldam, Daan Nieboer, Ferran Algaba, Mahul B Amin, Dan M Berney, Athanase Billis, David G Bostwick, Lukas Bubendorf, Liang Cheng, Eva Compérat, Brett Delahunt, Lars Egevad, Andrew J Evans, Donna E Hansel, Peter A Humphrey, Glen Kristiansen, Theodorus H van der Kwast, Cristina Magi-Galluzzi, Rodolfo Montironi, George J Netto, Hemamali Samaratunga, John R Srigley, Puay H Tan, Murali Varma, Ming Zhou, Geert J L H van Leenders

Abstract

To assess the inter-observer reproducibility of individual Gleason grade 4 growth patterns. Twenty-three genitourinary pathologists participated in the evaluation of 60 selected high-magnification photographs. The selection included 10 cases of Gleason grade 3, 40 Gleason grade 4 (10 per growth pattern) and 10 Gleason grade 5. Participants were asked to select a single predominant Gleason grade per case (3, 4, 5) and to indicate the predominant Gleason grade 4 growth pattern if present. "Consensus" was defined as at least 80% agreement and "favoured" as 60-80% agreement. Consensus on Gleason grading was reached in 47/60 (78%) cases, 35 of which were assigned a grade 4. In the 13 non-consensus cases, ill-formed (6/13, 46%) and fused (7/13, 54%) patterns were involved in disagreement. Among the 20 cases where at least 1 pathologist assigned the ill-formed growth pattern none (0%, 0/20) reached consensus. Consensus for fused, cribriform and glomeruloid glands was reached in 2%, 23%, and 38%, respectively. In 9/35 (26%) consensus Gleason grade 4 cases, participants disagreed on growth pattern. Six of these were characterized by large epithelial proliferations with delicate intervening fibro-vascular cores, which were alternately given fused or cribriform growth pattern ("complex fused"). Consensus on Gleason grade 4 growth pattern was predominantly reached on cribriform and glomeruloid patterns, but rarely on ill-formed and fused glands. The complex fused glands seem to be a borderline pattern of unknown prognostic significance on which a consensus could not be reached. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Brazil 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 14%
Other 10 13%
Researcher 7 9%
Student > Master 7 9%
Student > Postgraduate 4 5%
Other 17 22%
Unknown 21 27%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Biochemistry, Genetics and Molecular Biology 7 9%
Engineering 3 4%
Agricultural and Biological Sciences 2 3%
Computer Science 2 3%
Other 10 13%
Unknown 31 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2019.
All research outputs
#1,542,442
of 24,549,201 outputs
Outputs from Histopathology
#86
of 3,414 outputs
Outputs of similar age
#27,840
of 340,341 outputs
Outputs of similar age from Histopathology
#1
of 41 outputs
Altmetric has tracked 24,549,201 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,414 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,341 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.