| Title |
Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis
|
|---|---|
| Published in |
Tumor Biology, March 2016
|
| DOI | 10.1007/s13277-016-5030-1 |
| Pubmed ID | |
| Authors |
Zhidan Mei, Li Zhou, Youhua Zhu, Kejia Jie, Daqing Fan, Jian Chen, Xiguo Liu, Liang Jiang, Qike Jia, Wei Li |
| Abstract |
Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that sex-determining region Y-box 17 (Sox17) is directly targeted by miR-595. We then demonstrated that IL-22 regulated migration and invasion of PTC cells via inhibiting Sox17 expression. Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17 downregulated compared with normal thyroid, and their expression levels were closely correlated. Taken together, this present study suggests that IL-22 stimulation enhances the migration and invasion of PTC cells by regulating miR-595 and its target Sox17. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 27% |
| Other | 2 | 13% |
| Student > Ph. D. Student | 2 | 13% |
| Professor | 1 | 7% |
| Lecturer | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 33% |
| Medicine and Dentistry | 3 | 20% |
| Agricultural and Biological Sciences | 2 | 13% |
| Unknown | 5 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2016.
All research outputs
#20,317,110
of 22,858,915 outputs
Outputs from Tumor Biology
#1,834
of 2,622 outputs
Outputs of similar age
#254,996
of 300,926 outputs
Outputs of similar age from Tumor Biology
#45
of 56 outputs
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