| Title |
The Inflammatory Response in Psoriasis: a Comprehensive Review
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, March 2016
|
| DOI | 10.1007/s12016-016-8535-x |
| Pubmed ID | |
| Authors |
Yaxiong Deng, Christopher Chang, Qianjin Lu |
| Abstract |
Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. However, psoriasis is thought to result from a combination of genetic, epigenetic, and environmental influences. Recent studies have identified that epigenetic factors including dysregulated DNA methylation levels, abnormal histone modification and microRNAs expressions are involved in the development of psoriasis. The interplay of immune cells and cytokines is another critical factor in the pathogenesis of psoriasis. These factors or pathways include Th1/Th2 homeostasis, the Th17/Treg balance and the IL-23/Th17 axis. Th17 is believed particularly important in psoriasis due to its pro-inflammatory effects and its involvement in an integrated inflammatory loop with dendritic cells and keratinocytes, contributing to an overproduction of antimicrobial peptides, inflammatory cytokines, and chemokines that leads to amplification of the immune response. In addition, other pathways and signaling molecules have been found to be involved, including Th9, Th22, regulatory T cells, γδ T cells, CD8(+) T cells, and their related cytokines. Understanding the pathogenesis of psoriasis will allow us to develop increasingly efficient targeted treatment by blocking relevant inflammatory signaling pathways and molecules. There is no cure for psoriasis at the present time, and much of the treatment involves managing the symptoms. The biologics, while lacking the adverse effects associated with some of the traditional medications such as corticosteroids and methotrexate, have their own set of side effects, which may include reactivation of latent infections. Significant challenges remain in developing safe and efficacious novel targeted therapies that depend on a better understanding of the immunological dysfunction in psoriasis. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 18% |
| Argentina | 1 | 6% |
| Venezuela, Bolivarian Republic of | 1 | 6% |
| France | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 10 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 71% |
| Scientists | 2 | 12% |
| Science communicators (journalists, bloggers, editors) | 2 | 12% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 360 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 360 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 56 | 16% |
| Student > Postgraduate | 45 | 13% |
| Student > Ph. D. Student | 36 | 10% |
| Researcher | 35 | 10% |
| Student > Master | 33 | 9% |
| Other | 60 | 17% |
| Unknown | 95 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 70 | 19% |
| Biochemistry, Genetics and Molecular Biology | 50 | 14% |
| Agricultural and Biological Sciences | 35 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 30 | 8% |
| Immunology and Microbiology | 29 | 8% |
| Other | 38 | 11% |
| Unknown | 108 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2023.
All research outputs
#2,097,371
of 25,079,481 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#71
of 703 outputs
Outputs of similar age
#33,714
of 306,585 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#2
of 12 outputs
Altmetric has tracked 25,079,481 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 703 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,585 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.