Title |
Role of Feline Immunodeficiency Virus in Lymphomagenesis—Going Alone or Colluding?
|
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Published in |
ILAR Journal, March 2016
|
DOI | 10.1093/ilar/ilv047 |
Pubmed ID | |
Authors |
Sarah Kaye, Wenqi Wang, Craig Miller, Alicia McLuckie, Julia A. Beatty, Chris K. Grant, Sue VandeWoude, Helle Bielefeldt-Ohmann |
Abstract |
Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and nondomestic feline species. Infection in domestic cats leads to immune dysfunction via mechanisms similar to those caused by human immunodeficiency virus (HIV) and, as such, is a valuable natural animal model for acquired immunodeficiency syndrome (AIDS) in humans. An association between FIV and an increased incidence of neoplasia has long been recognized, with frequencies of up to 20% in FIV-positive cats recorded in some studies. This is similar to the rate of neoplasia seen in HIV-positive individuals, and in both species neoplasia typically requires several years to arise. The most frequently reported type of neoplasia associated with FIV infection is lymphoma. Here we review the possible mechanisms involved in FIV lymphomagenesis, including the possible involvement of coinfections, notably those with gamma-herpesviruses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 17% |
Student > Bachelor | 7 | 15% |
Researcher | 7 | 15% |
Other | 3 | 6% |
Student > Ph. D. Student | 2 | 4% |
Other | 5 | 10% |
Unknown | 16 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 17 | 35% |
Agricultural and Biological Sciences | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 8% |
Unknown | 17 | 35% |