Title |
Genetic Susceptibility to Fungal Infections: What is in the Genes?
|
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Published in |
Current Clinical Microbiology Reports, March 2016
|
DOI | 10.1007/s40588-016-0037-3 |
Pubmed ID | |
Authors |
Stacey A. Maskarinec, Melissa D. Johnson, John R. Perfect |
Abstract |
The development of severe fungal infections has long been associated with traditional risk factors such as profound immunosuppression, yet it remains challenging to understand why under similar conditions only some patients will develop these infections while others will not. Recent studies have demonstrated the importance of host genetic variation in influencing the severity and susceptibility to invasive fungal infections (IFIs). In this review, we examine selected primary immunodeficiencies characterized by their vulnerability to a narrow range of fungal pathogens, and then focus on recently identified genetic polymorphisms associated with an increased susceptibility to IFIs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 50% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 50% |
Scientists | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 17% |
Researcher | 10 | 17% |
Student > Bachelor | 9 | 15% |
Student > Master | 9 | 15% |
Lecturer | 3 | 5% |
Other | 7 | 12% |
Unknown | 11 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 24% |
Biochemistry, Genetics and Molecular Biology | 11 | 19% |
Medicine and Dentistry | 8 | 14% |
Immunology and Microbiology | 6 | 10% |
Environmental Science | 1 | 2% |
Other | 4 | 7% |
Unknown | 15 | 25% |