| Title |
VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients
|
|---|---|
| Published in |
Angiogenesis, March 2012
|
| DOI | 10.1007/s10456-012-9259-z |
| Pubmed ID | |
| Authors |
Jon E. Peterson, David Zurakowski, Joseph E. Italiano, Lea V. Michel, Susan Connors, Marsha Oenick, Robert J. D’Amato, Giannoula L. Klement, Judah Folkman |
| Abstract |
Platelets sequester angiogenesis regulatory proteins which suggests an avenue for developing biomarkers to monitor disease. We describe a comparison of angiogenesis regulatory proteins found in platelets of colorectal cancer patients and normal controls. Platelet and plasma content of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), platelet factor 4 (PF4), thrombospondin-1 (TSP-1) and endostatin in 35 patients with colon cancer were compared with 84 age-matched healthy controls using ELISAs. We standardized the platelet preparation procedure, introduced process controls and normalized the respective protein levels to platelet numbers using an actin ELISA. Statistically significant differences were found in the median levels of VEGF, PF4 and PDGF in platelets of patients with cancer compared to healthy individuals. Platelet concentrations in cancer patients versus controls were: VEGF 1.3 versus 0.6 pg/10(6), PF4 18.5 versus 9.4 ng/10(6), and PDGF 34.1 versus 21.0 pg/10(6). Multivariable logistic regression analysis indicated that PDGF, PF4 and VEGF were independent predictors of colorectal carcinoma and as a set provided statistically significant discrimination (area under the curve = 0.893, P < .0001). No significant differences were detected for bFGF, endostatin, or TSP-1. Reference Change Value analysis determined that the differences seen were not clinically significant. Plasma levels yielded no correlations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Ireland | 1 | 1% |
| Unknown | 96 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 23% |
| Student > Master | 13 | 13% |
| Researcher | 11 | 11% |
| Student > Doctoral Student | 9 | 9% |
| Student > Bachelor | 9 | 9% |
| Other | 19 | 19% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 26% |
| Biochemistry, Genetics and Molecular Biology | 19 | 19% |
| Agricultural and Biological Sciences | 16 | 16% |
| Engineering | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 20 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2022.
All research outputs
#7,284,400
of 22,979,862 outputs
Outputs from Angiogenesis
#172
of 538 outputs
Outputs of similar age
#49,941
of 156,975 outputs
Outputs of similar age from Angiogenesis
#5
of 13 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 538 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,975 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.