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Identifying metabolite markers for preterm birth in cervicovaginal fluid by magnetic resonance spectroscopy

Overview of attention for article published in Metabolomics, March 2016
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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73 Mendeley
Title
Identifying metabolite markers for preterm birth in cervicovaginal fluid by magnetic resonance spectroscopy
Published in
Metabolomics, March 2016
DOI 10.1007/s11306-016-0985-x
Pubmed ID
Authors

Emmanuel Amabebe, Steven Reynolds, Victoria L. Stern, Jennifer L. Parker, Graham P. Stafford, Martyn N. Paley, Dilly O. C. Anumba

Abstract

Preterm birth (PTB) may be preceded by changes in the vaginal microflora and metabolite profiles. We sought to characterise the metabolite profile of cervicovaginal fluid (CVF) of pregnant women by 1H NMR spectroscopy, and assess their predictive value for PTB. A pair of high-vaginal swabs was obtained from pregnant women with no evidence of clinical infection and grouped as follows: asymptomatic low risk (ALR) women with no previous history of PTB, assessed at 20-22 gestational weeks, g.w., n = 83; asymptomatic high risk (AHR) women with a previous history of PTB, assessed at both 20-22 g.w., n = 71, and 26-28 g.w., n = 58; and women presenting with symptoms of preterm labor (PTL) (SYM), assessed at 24-36 g.w., n = 65. Vaginal secretions were dissolved in phosphate buffered saline and scanned with a 9.4 T NMR spectrometer. Six metabolites (lactate, alanine, acetate, glutamine/glutamate, succinate and glucose) were analysed. In all study cohorts vaginal pH correlated with lactate integral (r = -0.62, p < 0.0001). Lactate integrals were higher in the term ALR compared to the AHR (20-22 g.w.) women (p = 0.003). Acetate integrals were higher in the preterm versus term women for the AHR (20-22 g.w.) (p = 0.048) and SYM (p = 0.003) groups; and was predictive of PTB < 37 g.w. (AUC 0.78; 95 % CI 0.61-0.95), and delivery within 2 weeks of the index assessment (AUC 0.84; 95 % CI 0.64-1) in the SYM women, whilst other metabolites were not. High CVF acetate integral of women with symptoms of PTL appears predictive of preterm delivery, as well as delivery within 2 weeks of presentation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 22%
Student > Master 12 16%
Researcher 7 10%
Student > Bachelor 6 8%
Student > Doctoral Student 5 7%
Other 12 16%
Unknown 15 21%
Readers by discipline Count As %
Medicine and Dentistry 22 30%
Biochemistry, Genetics and Molecular Biology 15 21%
Agricultural and Biological Sciences 4 5%
Immunology and Microbiology 3 4%
Nursing and Health Professions 3 4%
Other 11 15%
Unknown 15 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2021.
All research outputs
#5,803,596
of 23,316,003 outputs
Outputs from Metabolomics
#306
of 1,309 outputs
Outputs of similar age
#79,997
of 300,619 outputs
Outputs of similar age from Metabolomics
#13
of 53 outputs
Altmetric has tracked 23,316,003 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,619 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.