Title |
Breast cancer risk in Chinese women with BRCA1 or BRCA2 mutations
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Published in |
Breast Cancer Research and Treatment, March 2016
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DOI | 10.1007/s10549-016-3766-3 |
Pubmed ID | |
Authors |
Lu Yao, Jie Sun, Juan Zhang, Yingjian He, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie |
Abstract |
BRCA1/2 mutations represent approximately 5 % of unselected Chinese women with breast cancer. However, the breast cancer risk of Chinese women with BRCA1/2 mutations is unknown. Therefore, the aim of this study was to estimate the age-specific cumulative risk of breast cancer in Chinese women who carry a BRCA1 or BRCA2 mutation. Our study included 1816 unselected Chinese women with breast cancer and 5549 female first-degree relatives of these probands. All probands were screened for BRCA1/2 mutation. The age-specific cumulative risks of BRCA1/2 carriers were estimated using the kin-cohort study by comparing the history of breast cancer in first-degree female relatives of BRCA1/2 carriers and non-carriers. Among the 1816 probands, 125 BRCA1/2 pathogenic mutations were identified (70 in the BRCA1 gene and 55 in the BRCA2 gene). The incidence of breast cancer in the first-degree female relatives of BRCA1/2 mutation carriers was significantly higher (3.7-fold and 4.4-fold for BRCA1 and BRCA2 mutation carriers, respectively) than in non-carriers. The estimated cumulative risks of breast cancer by age 70 years were 37.9 % [95 % confidence interval (CI) 24.1-54.4 %] for BRCA1 mutation carriers and 36.5 % (95 % CI 26.7-51.8 %) for BRCA2 mutation carriers, respectively. Our study suggests that the breast cancer risk of Chinese women with BRCA1/2 mutations appears to be relatively high by the age of 70. Therefore, genetic counseling, enhanced surveillance, and individual preventive strategies should be provided for Chinese women who carry a BRCA1/2 mutation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 29% |
United Kingdom | 1 | 14% |
Canada | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 20% |
Researcher | 5 | 17% |
Student > Doctoral Student | 4 | 13% |
Other | 3 | 10% |
Student > Ph. D. Student | 2 | 7% |
Other | 4 | 13% |
Unknown | 6 | 20% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 30% |
Medicine and Dentistry | 7 | 23% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Business, Management and Accounting | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 27% |