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Is there a biological difference between trauma-related depression and PTSD? DST says ‘NO’

Overview of attention for article published in Psychoneuroendocrinology, March 2012
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Title
Is there a biological difference between trauma-related depression and PTSD? DST says ‘NO’
Published in
Psychoneuroendocrinology, March 2012
DOI 10.1016/j.psyneuen.2012.02.005
Pubmed ID
Authors

Danka Savic, Goran Knezevic, Svetozar Damjanovic, Zeljko Spiric, Gordana Matic

Abstract

The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 male participants: 57 with PTSD, 28 with depression, 76 with PTSD+depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5mg of dexamethasone (at 2300 h). Group means ± standard deviation of cortisol suppression were: 79.4±18.5 in the PTSD group, 80.8±11.6 in the depression group, 77.5±24.6 in the group with PTSD+depression, and 66.8±34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Canada 1 2%
Romania 1 2%
Korea, Republic of 1 2%
Serbia 1 2%
Unknown 45 90%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 8 16%
Student > Master 7 14%
Student > Doctoral Student 7 14%
Professor 4 8%
Student > Ph. D. Student 4 8%
Other 14 28%
Unknown 6 12%
Readers by discipline Count As %
Psychology 16 32%
Medicine and Dentistry 6 12%
Neuroscience 6 12%
Biochemistry, Genetics and Molecular Biology 2 4%
Unspecified 2 4%
Other 6 12%
Unknown 12 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2012.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Psychoneuroendocrinology
#3,181
of 3,903 outputs
Outputs of similar age
#132,208
of 168,626 outputs
Outputs of similar age from Psychoneuroendocrinology
#28
of 31 outputs
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