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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury
|
|---|---|
| Published in |
eLife, April 2016
|
| DOI | 10.7554/elife.12661 |
| Pubmed ID | |
| Authors |
Margarita Calvo, Natalie Richards, Annina B Schmid, Alejandro Barroso, Lan Zhu, Dinka Ivulic, Ning Zhu, Philipp Anwandter, Manzoor A Bhat, Felipe A Court, Stephen B McMahon, David LH Bennett |
| Abstract |
Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were hardly detectable in the naïve state, showed increased expression within juxtaparanodes and paranodes following injury, both in rats and humans. Within the dorsal root (a site remote from injury) we noted a redistribution of Kv1-channels towards the paranode. Blockade of Kv1 channels with αDTX after injury reinstated hyperexcitability of A-fibre axons and enhanced mechanosensitivity. Changes in the molecular composition and distribution of axonal Kv1 channels, therefore represents a protective mechanism to suppress the hyperexcitability of myelinated sensory axons that follows nerve injury. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Chile | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 21% |
| Researcher | 16 | 13% |
| Student > Bachelor | 13 | 11% |
| Student > Master | 10 | 8% |
| Student > Doctoral Student | 9 | 7% |
| Other | 23 | 19% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 43 | 36% |
| Medicine and Dentistry | 19 | 16% |
| Agricultural and Biological Sciences | 17 | 14% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Nursing and Health Professions | 3 | 2% |
| Other | 3 | 2% |
| Unknown | 27 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2017.
All research outputs
#8,094,730
of 24,990,015 outputs
Outputs from eLife
#11,656
of 15,273 outputs
Outputs of similar age
#107,108
of 306,123 outputs
Outputs of similar age from eLife
#200
of 305 outputs
Altmetric has tracked 24,990,015 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 15,273 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 305 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.