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Aging Does Not Reduce Heat Shock Protein 70 in the Absence of Chronic Insulin Resistance

Overview of attention for article published in Journals of Gerontology Series A: Biological Sciences & Medical Sciences, March 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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blogs
1 blog

Citations

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18 Dimensions

Readers on

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28 Mendeley
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Title
Aging Does Not Reduce Heat Shock Protein 70 in the Absence of Chronic Insulin Resistance
Published in
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, March 2012
DOI 10.1093/gerona/gls008
Pubmed ID
Authors

Kylie Kavanagh, Ashley T. Wylie, Tara J. Chavanne, Matthew J. Jorgensen, V. Saroja Voruganti, Anthony G. Comuzzie, Jay R. Kaplan, Charles E. McCall, Stephen B. Kritchevsky

Abstract

Heat shock protein (HSP)70 decreases with age. Often aging is associated with coincident insulin resistance and higher blood glucose levels, which also associate with lower HSP70. We aimed to understand how these factors interrelate through a series of experiments using vervet monkeys (Chlorocebus aethiops sabaeous). Monkeys (n = 284, 4-25 years) fed low-fat diets showed no association of muscle HSP70 with age (r = .04, p = .53), but levels were highly heritable. Insulin resistance was induced in vervet monkeys with high-fat diets, and muscle biopsies were taken after 0.3 or 6 years. HSP70 levels were significantly greater after 0.3 years (+72%, p < .05) but were significantly lower following 6 years of high-fat diet (-77%, p < .05). Associations with glucose also switched from being positive (r = .44, p = .03) to strikingly negative (r = -.84, p < .001) with increasing insulin resistance. In conclusion, a low-fat diet may preserve tissue HSP70 and health with aging, whereas high-fat diets, insulin resistance, and genetic factors may be more important than age for determining HSP70 levels.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Professor 5 18%
Student > Master 4 14%
Student > Ph. D. Student 4 14%
Researcher 3 11%
Student > Doctoral Student 2 7%
Other 6 21%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Agricultural and Biological Sciences 7 25%
Biochemistry, Genetics and Molecular Biology 6 21%
Neuroscience 3 11%
Social Sciences 1 4%
Other 1 4%
Unknown 3 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2012.
All research outputs
#4,158,118
of 25,374,647 outputs
Outputs from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#1,304
of 3,968 outputs
Outputs of similar age
#25,697
of 168,682 outputs
Outputs of similar age from Journals of Gerontology Series A: Biological Sciences & Medical Sciences
#17
of 56 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,968 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,682 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.