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X Demographics
Mendeley readers
Attention Score in Context
| Title |
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
|
|---|---|
| Published in |
Nature, April 2016
|
| DOI | 10.1038/nature17392 |
| Pubmed ID | |
| Authors |
Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel, Vanessa M. Dang, Jessica Appleton, Michael P. O’Connell, Phil Cheng, Alexander A. Valiga, Rachel Morissette, Nazli B. McDonnell, Luigi Ferrucci, Andrew V. Kossenkov, Katrina Meeth, Hsin-Yao Tang, Xiangfan Yin, William H. Wood, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas, Ashani T. Weeraratna |
| Abstract |
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment on tumour progression have been largely unexplored. Since dermal fibroblasts can have profound impacts on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive melanoma metastasis and response to targeted therapy. Here we find that aged fibroblasts secrete a Wnt antagonist, sFRP2, which activates a multi-step signalling cascade in melanoma cells that results in a decrease in β-catenin and microphthalmia-associated transcription factor (MITF), and ultimately the loss of a key redox effector, APE1. Loss of APE1 attenuates the response of melanoma cells to DNA damage induced by reactive oxygen species, rendering the cells more resistant to targeted therapy (vemurafenib). Age-related increases in sFRP2 also augment both angiogenesis and metastasis of melanoma cells. These data provide an integrated view of how fibroblasts in the aged microenvironment contribute to tumour progression, offering new possibilities for the design of therapy for the elderly. |
X Demographics
The data shown below were collected from the profiles of 97 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 34 | 35% |
| Canada | 6 | 6% |
| United Kingdom | 3 | 3% |
| France | 3 | 3% |
| Japan | 2 | 2% |
| Israel | 1 | 1% |
| Singapore | 1 | 1% |
| Australia | 1 | 1% |
| Austria | 1 | 1% |
| Other | 7 | 7% |
| Unknown | 38 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 65 | 67% |
| Scientists | 22 | 23% |
| Practitioners (doctors, other healthcare professionals) | 7 | 7% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 409 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Denmark | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 399 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 97 | 24% |
| Researcher | 84 | 21% |
| Student > Master | 40 | 10% |
| Other | 32 | 8% |
| Student > Bachelor | 30 | 7% |
| Other | 55 | 13% |
| Unknown | 71 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 125 | 31% |
| Agricultural and Biological Sciences | 85 | 21% |
| Medicine and Dentistry | 60 | 15% |
| Immunology and Microbiology | 16 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
| Other | 34 | 8% |
| Unknown | 82 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 279. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#129,885
of 25,728,350 outputs
Outputs from Nature
#8,492
of 98,595 outputs
Outputs of similar age
#2,348
of 315,505 outputs
Outputs of similar age from Nature
#194
of 1,009 outputs
Altmetric has tracked 25,728,350 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,595 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,009 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.