| Title |
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer
|
|---|---|
| Published in |
Breast Cancer Research, March 2012
|
| DOI | 10.1186/bcr3134 |
| Pubmed ID | |
| Authors |
Fuqin Su, Fangli Ren, Yu Rong, Yangmeng Wang, Yongtao Geng, Yinyin Wang, Mengyao Feng, Yanfang Ju, Yi Li, Zhizhuang J Zhao, Kun Meng, Zhijie Chang |
| Abstract |
Signal transducer and activator of transcription 3 (STAT3) is over-activated or phosphorylated in breast cancers. The hyper-phosphorylation of STAT3 was attributed to either up-regulated phosphorylation by several tyrosine-kinases or down-regulated activity of phosphatases. Although several factors have been identified to phosphorylate STAT3, it remains unclear how STAT3 is dephosphorylated by PTPMeg2. The aim of this study was to determine the role of PTPMeg2 as a phosphatase in regulation of the activity of STAT3 in breast cancers. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 23% |
| Student > Ph. D. Student | 5 | 23% |
| Student > Doctoral Student | 3 | 14% |
| Student > Bachelor | 2 | 9% |
| Professor > Associate Professor | 2 | 9% |
| Other | 2 | 9% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 32% |
| Biochemistry, Genetics and Molecular Biology | 6 | 27% |
| Arts and Humanities | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Physics and Astronomy | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 4 | 18% |