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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1
|
|---|---|
| Published in |
Nature Immunology, April 2016
|
| DOI | 10.1038/ni.3416 |
| Pubmed ID | |
| Authors |
Hamish E G McWilliam, Sidonia B G Eckle, Alex Theodossis, Ligong Liu, Zhenjun Chen, Jacinta M Wubben, David P Fairlie, Richard A Strugnell, Justine D Mintern, James McCluskey, Jamie Rossjohn, Jose A Villadangos |
| Abstract |
The antigen-presenting molecule MR1 presents vitamin B-related antigens (VitB antigens) to mucosal-associated invariant T (MAIT) cells through an uncharacterized pathway. We show that MR1, unlike other antigen-presenting molecules, does not constitutively present self-ligands. In the steady state it accumulates in a ligand-receptive conformation within the endoplasmic reticulum. VitB antigens reach this location and form a Schiff base with MR1, triggering a 'molecular switch' that allows MR1-VitB antigen complexes to traffic to the plasma membrane. These complexes are endocytosed with kinetics independent of the affinity of the MR1-ligand interaction and are degraded intracellularly, although some MR1 molecules acquire new ligands during passage through endosomes and recycle back to the surface. MR1 antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 20% |
| United States | 1 | 20% |
| Australia | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 161 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 22% |
| Researcher | 29 | 18% |
| Student > Bachelor | 16 | 10% |
| Student > Doctoral Student | 10 | 6% |
| Student > Master | 10 | 6% |
| Other | 22 | 13% |
| Unknown | 40 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 46 | 28% |
| Agricultural and Biological Sciences | 31 | 19% |
| Biochemistry, Genetics and Molecular Biology | 25 | 15% |
| Medicine and Dentistry | 11 | 7% |
| Chemistry | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 41 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2020.
All research outputs
#1,929,242
of 22,860,626 outputs
Outputs from Nature Immunology
#1,059
of 3,811 outputs
Outputs of similar age
#33,907
of 300,360 outputs
Outputs of similar age from Nature Immunology
#29
of 66 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,811 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.