Title |
A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, August 2010
|
DOI | 10.1007/s10803-010-1078-8 |
Pubmed ID | |
Authors |
Stephen Bent, Kiah Bertoglio, Paul Ashwood, Alan Bostrom, Robert L. Hendren |
Abstract |
We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3-8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (± 4.8) points in the omega-3 group compared to 0.3 (± 7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects. |
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Geographical breakdown
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Saudi Arabia | 3 | 33% |
United Kingdom | 1 | 11% |
United States | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
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Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
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Japan | 2 | 1% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Unknown | 194 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 44 | 22% |
Student > Master | 33 | 17% |
Researcher | 19 | 10% |
Other | 16 | 8% |
Student > Ph. D. Student | 16 | 8% |
Other | 34 | 17% |
Unknown | 36 | 18% |
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Medicine and Dentistry | 50 | 25% |
Psychology | 22 | 11% |
Agricultural and Biological Sciences | 20 | 10% |
Nursing and Health Professions | 17 | 9% |
Neuroscience | 11 | 6% |
Other | 30 | 15% |
Unknown | 48 | 24% |