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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Combinatorial Activation and Repression by Seven Transcription Factors Specify Drosophila Odorant Receptor Expression
|
|---|---|
| Published in |
PLoS Biology, March 2012
|
| DOI | 10.1371/journal.pbio.1001280 |
| Pubmed ID | |
| Authors |
Shadi Jafari, Liza Alkhori, Alexander Schleiffer, Anna Brochtrup, Thomas Hummel, Mattias Alenius |
| Abstract |
The mechanism that specifies olfactory sensory neurons to express only one odorant receptor (OR) from a large repertoire is critical for odor discrimination but poorly understood. Here, we describe the first comprehensive analysis of OR expression regulation in Drosophila. A systematic, RNAi-mediated knock down of most of the predicted transcription factors identified an essential function of acj6, E93, Fer1, onecut, sim, xbp1, and zf30c in the regulation of more than 30 ORs. These regulatory factors are differentially expressed in antennal sensory neuron classes and specifically required for the adult expression of ORs. A systematic analysis reveals not only that combinations of these seven factors are necessary for receptor gene expression but also a prominent role for transcriptional repression in preventing ectopic receptor expression. Such regulation is supported by bioinformatics and OR promoter analyses, which uncovered a common promoter structure with distal repressive and proximal activating regions. Thus, our data provide insight into how combinatorial activation and repression can allow a small number of transcription factors to specify a large repertoire of neuron classes in the olfactory system. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| United Kingdom | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 3% |
| Germany | 5 | 3% |
| Portugal | 2 | 1% |
| India | 1 | <1% |
| Ireland | 1 | <1% |
| Unknown | 142 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 31% |
| Researcher | 32 | 21% |
| Student > Master | 15 | 10% |
| Student > Bachelor | 10 | 6% |
| Professor > Associate Professor | 9 | 6% |
| Other | 24 | 15% |
| Unknown | 17 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 94 | 60% |
| Biochemistry, Genetics and Molecular Biology | 23 | 15% |
| Neuroscience | 13 | 8% |
| Immunology and Microbiology | 2 | 1% |
| Engineering | 2 | 1% |
| Other | 6 | 4% |
| Unknown | 16 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2012.
All research outputs
#2,435,442
of 25,654,806 outputs
Outputs from PLoS Biology
#3,450
of 9,148 outputs
Outputs of similar age
#13,989
of 169,759 outputs
Outputs of similar age from PLoS Biology
#24
of 69 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,148 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,759 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.