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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors*
|
|---|---|
| Published in |
Journal of Biological Chemistry, February 2016
|
| DOI | 10.1074/jbc.m115.708172 |
| Pubmed ID | |
| Authors |
Daniel J Frank, Yan Zhao, Siew Hoon Wong, Debashree Basudhar, James J De Voss, Paul R Ortiz de Montellano |
| Abstract |
Cholest-4-en-3-one, whether added exogenously or generated intracellularly from cholesterol, inhibits the growth of Mycobacterium tuberculosis when CYP125A1 and CYP142A1, the cytochrome P450 enzymes that initiate degradation of the sterol side-chain, are disabled. Here we demonstrate that a 16-hydroxy derivative of cholesterol, which was previously reported to inhibit growth of M. tuberculosis, acts by preventing the oxidation of the sterol side-chain even in the presence of the relevant cytochrome P450 enzymes. The finding that (25R)-cholest-5-en-3β, 16β, 26-triol (1) (and its 3-keto metabolite) inhibit growth suggests that cholesterol analogs with non-degradable side-chains represent a novel class of anti-mycobacterial agents. In accord with this, two cholesterol analogs with truncated, fluorinated side-chains have been synthesized and shown to similarly block the growth in culture of M. tuberculosis. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| France | 1 | 14% |
| Turkey | 1 | 14% |
| Venezuela, Bolivarian Republic of | 1 | 14% |
| South Africa | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 35 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 29% |
| Student > Bachelor | 7 | 20% |
| Student > Master | 4 | 11% |
| Researcher | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 23% |
| Agricultural and Biological Sciences | 8 | 23% |
| Chemistry | 5 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Immunology and Microbiology | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 7 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 106. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2016.
All research outputs
#395,694
of 25,377,790 outputs
Outputs from Journal of Biological Chemistry
#121
of 85,237 outputs
Outputs of similar age
#7,215
of 406,429 outputs
Outputs of similar age from Journal of Biological Chemistry
#5
of 421 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,237 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,429 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 421 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.