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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Overview of attention for article published in The Lancet, March 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
2 news outlets
blogs
3 blogs
twitter
69 X users
patent
7 patents
facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
882 Dimensions

Readers on

mendeley
630 Mendeley
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Title
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Published in
The Lancet, March 2012
DOI 10.1016/s0140-6736(12)60110-x
Pubmed ID
Authors

Daniel I Swerdlow, Michael V Holmes, Karoline B Kuchenbaecker, Jorgen E L Engmann, Tina Shah, Reecha Sofat, Yiran Guo, Christina Chung, Anne Peasey, Roman Pfister, Simon P Mooijaart, Helen A Ireland, Maarten Leusink, Claudia Langenberg, Ka Wah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, John Hardy, Michael A Nalls, Yun Rose Li, Gordon Lowe, Marlene Stewart, Suzette J Bielinski, Julian Peto, Nicholas J Timpson, John Gallacher, Malcolm Dunlop, Richard Houlston, Ian Tomlinson, Ioanna Tzoulaki, Jian'an Luan, Jolanda M A Boer, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Luigi Ferrucci, Stefania Bandenelli, Toshiko Tanaka, James F Meschia, Andrew Singleton, Gerjan Navis, Irene Mateo Leach, Stephan J L Bakker, Ron T Gansevoort, Ian Ford, Stephen E Epstein, Mary Susan Burnett, Joe M Devaney, J Wouter Jukema, Rudi G J Westendorp, Gert Jan de Borst, Yolanda van der Graaf, Pim A de Jong, Anke-Hilse Mailand-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Jeffrey W Stephens, Charles B Eaton, Jennifer G Robinson, JoAnn E Manson, F Gerry Fowkes, Timonthy M Frayling, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Susan Redline, Leslie A Lange, Meena Kumari, Nick J Wareham, W M Monique Verschuren, Emelia J Benjamin, John C Whittaker, Anders Hamsten, Frank Dudbridge, J A Chris Delaney, Andrew Wong, Diana Kuh, Rebecca Hardy, Berta Almoguera Castillo, John J Connolly, Pim van der Harst, Eric J Brunner, Michael G Marmot, Christina L Wassel, Steve E Humphries, Philippa J Talmud, Mika Kivimaki, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Hakon Hakonarson, Alex P Reiner, Brendan J Keating, Naveed Sattar, Aroon D Hingorani, Juan Pablo Casas

Abstract

A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoid arthritis reduces systemic and articular inflammation. However, whether IL6R blockade also reduces risk of coronary heart disease is unknown.

X Demographics

X Demographics

The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 630 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
United Kingdom 5 <1%
Netherlands 2 <1%
Spain 2 <1%
Germany 2 <1%
Italy 1 <1%
Hong Kong 1 <1%
Switzerland 1 <1%
France 1 <1%
Other 7 1%
Unknown 603 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 114 18%
Researcher 114 18%
Student > Master 55 9%
Other 46 7%
Student > Bachelor 46 7%
Other 129 20%
Unknown 126 20%
Readers by discipline Count As %
Medicine and Dentistry 229 36%
Agricultural and Biological Sciences 81 13%
Biochemistry, Genetics and Molecular Biology 57 9%
Nursing and Health Professions 17 3%
Immunology and Microbiology 15 2%
Other 74 12%
Unknown 157 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 85. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2024.
All research outputs
#502,518
of 25,513,063 outputs
Outputs from The Lancet
#4,657
of 42,787 outputs
Outputs of similar age
#2,227
of 169,247 outputs
Outputs of similar age from The Lancet
#36
of 489 outputs
Altmetric has tracked 25,513,063 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 42,787 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 68.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,247 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 489 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.