| Title |
Triclosan promotes epicutaneous sensitization to peanut in mice
|
|---|---|
| Published in |
Clinical and Translational Allergy, April 2016
|
| DOI | 10.1186/s13601-016-0102-2 |
| Pubmed ID | |
| Authors |
Steven Tobar, Leticia Tordesillas, M. Cecilia Berin |
| Abstract |
Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is a need to identify environmental factors that promote epicutaneous sensitization to peanut. Triclosan is an antimicrobial found in household products that has been associated with food sensitization in humans. We tested the impact of triclosan on epicutaneous sensitization to peanut, as well as the milk allergen α-lactalbumin (ALA). We observed that topical triclosan promoted epicutaneous sensitization to both peanut and ALA, and promoted anaphylaxis to peanut. Our results demonstrate that the mouse model of epicutaneous sensitization to foods is effective for demonstrating the clinically significant impact of environmental factors such as triclosan on food allergy. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 14% |
| United States | 1 | 7% |
| France | 1 | 7% |
| Australia | 1 | 7% |
| Netherlands | 1 | 7% |
| Canada | 1 | 7% |
| Taiwan | 1 | 7% |
| Switzerland | 1 | 7% |
| Unknown | 5 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 50% |
| Scientists | 4 | 29% |
| Practitioners (doctors, other healthcare professionals) | 3 | 21% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 28% |
| Researcher | 5 | 17% |
| Student > Master | 4 | 14% |
| Student > Bachelor | 3 | 10% |
| Professor | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 5 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 6 | 21% |
| Agricultural and Biological Sciences | 5 | 17% |
| Medicine and Dentistry | 4 | 14% |
| Chemistry | 3 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2016.
All research outputs
#1,572,990
of 23,613,071 outputs
Outputs from Clinical and Translational Allergy
#56
of 688 outputs
Outputs of similar age
#27,539
of 302,281 outputs
Outputs of similar age from Clinical and Translational Allergy
#1
of 12 outputs
Altmetric has tracked 23,613,071 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 688 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,281 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.