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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
|
|---|---|
| Published in |
PLoS Genetics, March 2012
|
| DOI | 10.1371/journal.pgen.1002548 |
| Pubmed ID | |
| Authors |
Christina M. Lill, Johannes T. Roehr, Matthew B. McQueen, Fotini K. Kavvoura, Sachin Bagade, Brit-Maren M. Schjeide, Leif M. Schjeide, Esther Meissner, Ute Zauft, Nicole C. Allen, Tian Liu, Marcel Schilling, Kari J. Anderson, Gary Beecham, Daniela Berg, Joanna M. Biernacka, Alexis Brice, Anita L. DeStefano, Chuong B., Nicholas Eriksson, Stewart A. Factor, Matthew J. Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A. Hardy, Peter Heutink, Erin M. Hill-Burns, Christine Klein, Jeanne C. Latourelle, Demetrius M. Maraganore, Eden R. Martin, Maria Martinez, Richard H. Myers, Michael A. Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K. Scott, Manu Sharma, Andrew B. Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y. Tung, Jeffery Vance, Nick W. Wood, Cyrus P. Zabetian, The Genetic Epidemiology of Parkinson's Disease Consortium 23andMe, The International Parkinson's Disease Genomics Consortium, The Parkinson's Disease GWAS Consortium, The Wellcome Trust Case Control Consortium, Peter Young, Rudolph E. Tanzi, Muin J. Khoury, Frauke Zipp, Hans Lehrach, John P. A. Ioannidis, Lars Bertram |
| Abstract |
More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of -27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Meta-analyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P < 5 × 10(-8)) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P = 1.3 × 10(-8)). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 422 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| Germany | 6 | 1% |
| United Kingdom | 4 | <1% |
| Portugal | 1 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| South Africa | 1 | <1% |
| Israel | 1 | <1% |
| Colombia | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 395 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 88 | 21% |
| Student > Ph. D. Student | 79 | 19% |
| Student > Master | 47 | 11% |
| Student > Bachelor | 41 | 10% |
| Professor | 22 | 5% |
| Other | 81 | 19% |
| Unknown | 64 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 106 | 25% |
| Medicine and Dentistry | 73 | 17% |
| Biochemistry, Genetics and Molecular Biology | 59 | 14% |
| Neuroscience | 43 | 10% |
| Computer Science | 12 | 3% |
| Other | 44 | 10% |
| Unknown | 85 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2023.
All research outputs
#1,406,438
of 25,628,260 outputs
Outputs from PLoS Genetics
#1,054
of 8,993 outputs
Outputs of similar age
#7,260
of 169,588 outputs
Outputs of similar age from PLoS Genetics
#11
of 179 outputs
Altmetric has tracked 25,628,260 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,993 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,588 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 179 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.